The role of endothelial progenitor cells in prevascularized bone tissue engineering: development of heterogeneous constructs

NE Fedorovich, RT Haverslag, WJA Dhert… - … Engineering Part A, 2010 - liebertpub.com
In vitro prevascularization of bone grafts with endothelial progenitor cells (EPCs) is a
promising strategy to improveimplant survival. In this study we show bone formation in …

The use of endothelial progenitor cells for prevascularized bone tissue engineering

J Rouwkema, PE Westerweel, J de Boer… - … Engineering Part A, 2009 - liebertpub.com
In vitro vascularization is an upcoming strategy to solve the problem of insufficient blood
supply after implantation. Although recent publications show promising results, these studies …

Differential analysis of peripheral blood‐and bone marrow‐derived endothelial progenitor cells for enhanced vascularization in bone tissue engineering

AR Amini, CT Laurencin… - Journal of orthopaedic …, 2012 - Wiley Online Library
For tissue engineering applications, effective bone regeneration requires rapid neo‐
vascularization of implanted grafts to ensure the survival of cells in the early post …

Promotion of osteogenesis in tissue‐engineered bone by pre‐seeding endothelial progenitor cells‐derived endothelial cells

H Yu, PJ VandeVord, W Gong, B Wu… - Journal of …, 2008 - Wiley Online Library
In addition to a biocompatible scaffold and an osteogenic cell population, tissue‐engineered
bone requires an appropriate vascular bed to overcome the obstacle of nutrient and oxygen …

Composite implantation of mesenchymal stem cells with endothelial progenitor cells enhances tissue‐engineered bone formation

K Usami, H Mizuno, K Okada, Y Narita… - … Research Part A: An …, 2009 - Wiley Online Library
For successful tissue engineering, neovascularization of the implanted tissue is critical.
Factors generated by endothelial cells are also considered crucial for the process of …

Differentiation of rabbit bone mesenchymal stem cells into endothelial cells in vitro and promotion of defective bone regeneration in vivo

J Liu, C Liu, B Sun, C Shi, C Qiao, X Ke, S Liu… - Cell Biochemistry and …, 2014 - Springer
Tissue engineering strategies often fail to regenerate bones because of inadequate
vascularization, especially in the reconstruction of large segmental bone defects. Large …

Influence of endothelial progenitor cells and platelet gel on tissue-engineered bone ectopically in goats

RE Geuze, F Wegman, F Cumhur Öner… - … Engineering Part A, 2009 - liebertpub.com
For the development of functional large bone tissue constructs, optimal oxygen and nutrients
supply of seeded multipotent stromal cells (MSCs) is likely dependent on vascularization …

Whatever their differentiation status, human progenitor derived–or mature–endothelial cells induce osteoblastic differentiation of bone marrow stromal cells

NB Thébaud, R Siadous, R Bareille… - Journal of tissue …, 2012 - Wiley Online Library
Association of the bone‐forming osteoblasts (OBs) and vascular endothelial cells (ECs) into
a biomaterial composite provides a live bone graft substitute that can repair the bone defect …

[PDF][PDF] Early endothelial progenitor cells as a source of myeloid cells to improve the pre-vascularisation of bone constructs

Y Shi, G Kramer, A Schröder, CJ Kirkpatrick… - Eur Cell …, 2014 - ecmjournal.org
According to present knowledge, blood derived endothelial progenitor cells (EPC) might act
as proangiogenic myeloid cells, which play a fundamental role in the regulation of …

Engineering vascularized bone graft with osteogenic and angiogenic lineage differentiated bone marrow mesenchymal stem cells

R Zhang, Z Gao, W Geng, X Yan, F Chen… - Artificial organs, 2012 - Wiley Online Library
Tissue‐engineered bone provides a promising method for the rehabilitation of acquired
bone defects and congenital deformities. However, generating a vascular supply to the …