Core promoters are minimal regions sufficient to direct accurate initiation of transcription and
are crucial for regulation of gene expression. They are highly diverse in terms of associated …

The identification and characterization of mammalian core promoters and transcription start
sites is a prerequisite to understanding how RNA polymerase II transcription is controlled …

One of the key events in eukaryotic gene regulation and consequent transcription is the
assembly of general transcription factors and RNA polymerase II into a functional pre …

Transcription initiation is a key regulatory step in the control of gene expression. Formation
of a preinitiation complex at the right time and at the right promoter is a prerequisite to …

Promoters are crucial for gene regulation. They vary greatly in terms of associated regulatory
elements, sequence motifs, the choice of transcription start sites and other features. Several …

The development of multicellular organisms and the uniqueness of each cell are achieved
by distinct transcriptional programs. Multiple processes that regulate gene expression …

Eukaryotic transcriptional regulation requires the integration of complex signals by the
transcriptional promoter. Distinct sequence elements, characteristic chromatin modifications …

Spatiotemporal control of gene expression is central to animal development. Core promoters
represent a previously unanticipated regulatory level by interacting with cis-regulatory …

The identities of different cells and tissues in multicellular organisms are determined by
tightly controlled transcriptional programs that enable accurate gene expression. The …

Recent studies using high-throughput sequencing protocols have uncovered the complexity
of mammalian transcription by RNA polymerase II, helping to define several initiation …