Fentanyl, a potent opioid analgesic that is used to treat cancer pain, is commonly
administered with paclitaxel in advanced tumors. However, the effect of fentanyl on the …

In this study, acetaminophen (APAP)-induced acute liver injury mice model was used to
investigate the effects of C2-ceramide and oltipraz on hepatocyte nuclear factor 1 (HNF-1) …

The objective of this study was to evaluate the in vivo metabolic profile of paclitaxel and to
examine the effect of potential co-administered drugs on the biliary secretion of paclitaxel …

No Heading Purpose. The aim of this study was to investigate the effect of hepatic or renal
insufficiency on the pharmacokinetics of paclitaxel in rats. Methods. Rats were treated with …

This study was to investigate the effect of apigenin on the bioavailability of paclitaxel after
oral and intravenous administration in rats. The effect of apigenin on P-glycoprotein (P-gp) …

Paclitaxel (PTX) is a widely used chemotherapeutic drug particularly effective against lung,
breast, and ovarian cancer, though its usefulness is limited due to its multi-organ toxicity …

Paclitaxel, one of the most effective chemotherapeutic drugs, is used to treat various cancers
but it is exceedingly toxic when used long‐term and can harm the liver. This study aimed to …

This study investigated the effect of macelignan on the P-glycoprotein-mediated drug efflux
as well as CYP3A4-mediated drug metabolism and subsequently its in vivo implication on …

Background: Cisplatin is a potent anticancer agent widely employed in chemotherapy.
However, cisplatin leads to toxicity on non-targeted healthy organs, including the liver. We …

Acetaminophen (APAP) is an antipyretic and analgesic, which is commonly associated with
drug‐induced hepatic injury. C2‐ceramide plays a key role in mediating cell life activities …