[HTML][HTML] An update review of emerging small-molecule therapeutic options for COVID-19

D Tian, Y Liu, C Liang, L Xin, X Xie, D Zhang… - Biomedicine & …, 2021 - Elsevier
The SARS-CoV-2 outbreak and pandemic that began near the end of 2019 has posed a
challenge to global health. At present, many candidate small-molecule therapeutics have …

Protease targeted COVID-19 drug discovery and its challenges: Insight into viral main protease (Mpro) and papain-like protease (PLpro) inhibitors

SA Amin, S Banerjee, K Ghosh, S Gayen… - Bioorganic & medicinal …, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) brutally perils physical and
mental health worldwide. Unavailability of effective anti-viral drug rendering global threat of …

Potential RNA-dependent RNA polymerase (RdRp) inhibitors as prospective drug candidates for SARS-CoV-2

MS Bekheit, SS Panda, AS Girgis - European Journal of Medicinal …, 2023 - Elsevier
The SARS-CoV-2 pandemic is considered as one of the most disastrous pandemics for
human health and the world economy. RNA-dependent RNA polymerase (RdRp) is one of …

Druggable targets of SARS-CoV-2 and treatment opportunities for COVID-19

BK Kumar, KVGC Sekhar, S Kunjiappan, J Jamalis… - Bioorganic …, 2020 - Elsevier
COVID-19 caused by the novel SARS-CoV-2 has been declared a pandemic by the WHO is
causing havoc across the entire world. As of May end, about 6 million people have been …

Recent drug development and medicinal chemistry approaches for the treatment of SARS‐CoV‐2 infection and COVID‐19

AK Ghosh, JL Mishevich, A Mesecar… - ChemMedChem, 2022 - Wiley Online Library
Abstract COVID‐19, caused by SARS‐CoV‐2 infection, continues to be a major public
health crisis around the globe. Development of vaccines and the first cluster of antiviral …

Identification of 14 known drugs as inhibitors of the main protease of SARS-CoV-2

MM Ghahremanpour, J Tirado-Rives… - ACS medicinal …, 2020 - ACS Publications
A consensus virtual screening protocol has been applied to ca. 2000 approved drugs to
seek inhibitors of the main protease (Mpro) of SARS-CoV-2, the virus responsible for COVID …

[HTML][HTML] Identifying small-molecule inhibitors of SARS-CoV-2 RNA-dependent RNA polymerase by establishing a fluorometric assay

X Bai, H Sun, S Wu, Y Li, L Wang, B Hong - Frontiers in Immunology, 2022 - frontiersin.org
SARS-CoV-2 (severe acute respiratory syndrome coronavirus‐2), a member of the
coronavirus family, appeared in 2019 and has caused the largest global public health and …

[HTML][HTML] Potency, safety, and pharmacokinetic profiles of potential inhibitors targeting SARS-CoV-2 main protease

HM Mengist, D Mekonnen, A Mohammed… - Frontiers in …, 2021 - frontiersin.org
Effective, safe, and pharmacokinetically suitable drugs are urgently needed to curb the
ongoing COVID-19 pandemic. The main protease or 3C-like protease (M pro or 3CL pro) of …

Potential inhibitors of SARS-CoV-2: recent advances

G Jamalipour Soufi, S Iravani - Journal of Drug Targeting, 2021 - Taylor & Francis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appeared in 2019 and is
the causative agent of the new pandemic viral disease COVID-19. The outbreak of COVID …

[HTML][HTML] Drug repurposing and polypharmacology to fight SARS-CoV-2 through inhibition of the main protease

L Pinzi, A Tinivella, F Caporuscio… - Frontiers in …, 2021 - frontiersin.org
The outbreak of a new coronavirus (SARS-CoV-2), which is responsible for the COVID-19
disease and is spreading rapidly around the world, urgently requires effective therapeutic …