[HTML][HTML] Untargeted multiomics approach coupling lipidomics and metabolomics profiling reveals new insights in diabetic retinopathy

P Ancel, JC Martin, E Doukbi, M Houssays… - International Journal of …, 2023 - mdpi.com
Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus (DM) which is
the main cause of vision loss in the working-age population. Currently known risk factors …

[HTML][HTML] Integrated analysis of metabolomics and lipidomics in plasma of T2DM patients with diabetic retinopathy

C Ding, N Wang, Z Wang, W Yue, B Li, J Zeng… - Pharmaceutics, 2022 - mdpi.com
Diabetic retinopathy (DR) is a major cause of blindness worldwide and may be non-
proliferative (NPDR) or proliferative (PDR). To investigate the metabolomic and lipidomic …

Multiplatform metabolomics reveals novel serum metabolite biomarkers in diabetic retinopathy subjects

Q Xuan, Y Ouyang, Y Wang, L Wu, H Li… - Advanced …, 2020 - Wiley Online Library
Diabetic retinopathy (DR) is the main cause of vision loss or blindness in working age adults
worldwide. The lack of effective diagnostic biomarkers for DR leads to unsatisfactory curative …

[HTML][HTML] Serum untargeted metabolomics reveal potential biomarkers of progression of diabetic retinopathy in Asians

Z Wang, J Tang, E Jin, Y Zhong, L Zhang… - Frontiers in Molecular …, 2022 - frontiersin.org
Purpose: To reveal molecular mechanisms of diabetic retinopathy (DR) in Asians and
facilitate the identification of new therapeutic targets through untargeted metabolomics. To …

[HTML][HTML] Metabolomics profiles associated with diabetic retinopathy in type 2 diabetes patients

JH Yun, JM Kim, HJ Jeon, T Oh, HJ Choi, BJ Kim - PLoS One, 2020 - journals.plos.org
Diabetic retinopathy (DR) is a common complication of diabetes, and it is the consequence
of microvascular retinal changes due to high glucose levels over a long time. Metabolomics …

[HTML][HTML] Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy

X Du, L Yang, L Kong, Y Sun, K Shen, Y Cai… - Frontiers in …, 2022 - frontiersin.org
Diabetic retinopathy (DR) is a universal microvascular complication of diabetes mellitus
(DM), which is the main reason for global sight damage/loss in middle-aged and/or older …

Integration of vitreous lipidomics and metabolomics for comprehensive understanding of the pathogenesis of proliferative diabetic retinopathy

J Fang, H Wang, T Niu, X Shi, X Xing… - Journal of Proteome …, 2023 - ACS Publications
As a vision-threatening complication of diabetes mellitus (DM), proliferative diabetic
retinopathy (PDR) is associated with sustained metabolic disorders. Herein, we collected the …

[HTML][HTML] Metabolomics in diabetic retinopathy: a systematic review

XW Hou, Y Wang, CW Pan - Investigative ophthalmology & …, 2021 - tvst.arvojournals.org
Purpose: Diabetic retinopathy (DR), a common microvascular complication of diabetes, is
the leading cause of acquired blindness in the working-age population. Individuals with …

[HTML][HTML] High-coverage serum metabolomics reveals metabolic pathway dysregulation in diabetic retinopathy: A propensity score-matched study

C Guo, D Jiang, Y Xu, F Peng, S Zhao, H Li… - Frontiers in Molecular …, 2022 - frontiersin.org
Background: Diabetic retinopathy (DR) is a major diabetes-related disease linked to
metabolism. However, the cognition of metabolic pathway alterations in DR remains scarce …

[HTML][HTML] Metabolomics in diabetic retinopathy: from potential biomarkers to molecular basis of oxidative stress

Q Jian, Y Wu, F Zhang - Cells, 2022 - mdpi.com
Diabetic retinopathy (DR), the leading cause of blindness in working-age adults, is one of
the most common complications of diabetes mellitus (DM) featured by metabolic disorders …