CD47, a broadly expressed cell surface protein, inhibits cell phagocytosis via interaction
with phagocyte-expressed SIRPα. A variety of hematological malignancies demonstrate …

CD47 is a widely expressed cell surface protein that functions as a regulator of phagocytosis
mediated by cells of the innate immune system, such as macrophages and dendritic cells …

CD47, expressed on a variety of tumor cells, confers immune resistance by delivering an
inhibitory “don't eat me” signal to phagocytic cells via its myeloid-specific receptor SIRPα …

Background: CD47 is a transmembrane protein ubiquitously expressed in human cells.
CD47 is overexpressed in various malignancies and is correlated with negative prognosis in …

ABSTRACT CD47 is a ubiquitously expressed cell surface glycoprotein that functions as a
signaling receptor for thrombospondin-1 and as the counter-receptor for signal regulatory …

CD47/SIRPα interaction serves as an immune checkpoint for macrophage-mediated
phagocytosis. Mouse anti-CD47 blocking antibodies had demonstrated potent efficacy in the …

CD47 is a widely expressed cell-surface protein that regulates phagocytosis mediated by
cells of the innate immune system, such as macrophages and dendritic cells. CD47 serves …

Highlights•CD47 is a “don't eat me” signal overexpressed on cancer cells.•Blockade of the
CD47–SIRPα signaling pathway leads to phagocytosis of tumor cells.•CD47–SIRPα …

Inhibitors of adaptive immune checkpoints have shown promise as cancer treatments. CD47
is an innate immune checkpoint receptor broadly expressed on normal tissues and …

Extensive clinical and experimental evidence suggests that macrophages play a crucial role
in cancer immunotherapy. Cluster of differentiation (CD) 47, which is found on both healthy …