Multiple-year experience in the diagnosis of viral central nervous system infections with a panel of polymerase chain reaction assays for detection of 11 viruses

C Huang, D Morse, B Slater, M Anand… - Clinical infectious …, 2004 - academic.oup.com
Background. Polymerase chain reaction (PCR) is becoming more common in diagnostic
laboratories. In some instances, its value has been established. In other cases, assays exist …

Management of viral central nervous system infections: a primer for clinicians

PB Bookstaver, PL Mohorn, A Shah… - Journal of central …, 2017 - journals.sagepub.com
Viruses are a common cause of central nervous system (CNS) infections with many host,
agent, and environmental factors influencing the expression of viral diseases. Viruses can …

Molecular detection of viral causes of encephalitis and meningitis in New York State

M Dupuis, R Hull, H Wang, S Nattanmai… - Journal of medical …, 2011 - Wiley Online Library
The etiology of encephalitis and meningitis, serious diseases of the central nervous system
(CNS), in most cases remains unknown. The importance of establishing a diagnosis …

Interpretation of positive molecular tests of common viruses in the cerebrospinal fluid

A Bhaskaran, L Racsa, R Gander, P Southern… - … and Infectious Disease, 2013 - Elsevier
Many central nervous system infections are historically difficult to diagnose. Polymerase
chain reaction (PCR) has revolutionized the diagnosis of these infections because of their …

Diagnosis of viral infections of the central nervous system: clinical interpretation of PCR results

KJM Jeffery, SJ Read, TEA Peto, RT Mayon-White… - The Lancet, 1997 - thelancet.com
Background Standard laboratory techniques, such as viral culture and serology, provide
only circumstantial or retrospective evidence of viral infections of the central nervous system …

Virological diagnosis of central nervous system infections by use of PCR coupled with mass spectrometry analysis of cerebrospinal fluid samples

N Lévêque, J Legoff, C Mengelle… - Journal of Clinical …, 2014 - Am Soc Microbiol
Viruses are the leading cause of central nervous system (CNS) infections, ahead of bacteria,
parasites, and fungal agents. A rapid and comprehensive virologic diagnostic testing …

Viral infections of the central nervous system: a case-based review

C Big, LA Reineck, DM Aronoff - Clinical medicine & research, 2009 - Marshfield Clinic
Three patients with viral infections of the central nervous system (CNS) were evaluated on
an inpatient infectious diseases consultation service within a two-week period. These cases …

Clinical application of viral cerebrospinal fluid PCR testing for diagnosis of central nervous system disorders: a retrospective 11-year experience

M Kleines, S Scheithauer, J Schiefer… - … microbiology and infectious …, 2014 - Elsevier
The cerebrospinal fluid (CSF) polymerase chain reaction (PCR) is the gold standard to
detect cerebral viral activity. As positive findings do not prove an impact on the neurological …

Factors influencing PCR detection of viruses in cerebrospinal fluid of patients with suspected CNS infections

NWS Davies, LJ Brown, J Gonde, D Irish… - Journal of Neurology …, 2005 - jnnp.bmj.com
Background: Polymerase chain reaction (PCR) is used to detect viruses in the cerebrospinal
fluid (CSF) of patients with neurological disease. However, data to assist its use or …

Molecular methods for diagnosis of viral encephalitis

RL DeBiasi, KL Tyler - Clinical microbiology reviews, 2004 - Am Soc Microbiol
Hundreds of viruses cause central nervous system (CNS) disease, including
meningoencephalitis and postinfectious encephalomyelitis, in humans. The cerebrospinal …