Cancer research has focused on the identification of molecular differences between
cancerous and healthy cells. The emerging picture is overwhelmingly complex. Molecules …

In order to understand how a cancer cell is functionally different from a normal cell it is
necessary to assess the complex network of pathways involving gene regulation, signaling …

Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell
type and tissue origin but also as a disease involving dysregulation of multiple pathways …

The transformation of normal cells into cancer cells and maintenance of the malignant state
and phenotypes are associated with genetic and epigenetic deregulations, altered cellular …

In the past decades, an enormous amount of precious information has been collected about
molecular and genetic characteristics of cancer. This knowledge is mainly based on a …

Traditionally, scientific research has focused on studying individual events, such as single
mutations, gene function, or the effect that mutating one protein has on a biological …

Cancer is a complex and heterogeneous disease that exhibits high levels of robustness
against various therapeutic interventions. It is a constellation of diverse and evolving …

An important challenge facing the field is how better to translate in vitro discoveries to the
clinic. Computational systems biology approaches that use omic data to predict biology …

The wealth of morphological, histological, and molecular data from human cancers available
to pathologists means that pathology is poised to become a truly quantitative systems …

The development of cost-effective technologies able to comprehensively assess DNA, RNA,
protein, and metabolites in patient tumors has fueled efforts to tailor medical care. Indeed …