Aging is the progressive decline or loss of function at the cellular, tissue, and organismal
levels that ultimately leads to death. A number of external and internal factors, including diet …

Aging is characterized by functional decline of diverse organs and an increased risk for
several diseases. Therefore, a high interest exists in understanding the molecular …

Aging represents the multifactorial decline in physiological function of every living organism.
Over the past decades, several hallmarks of aging have been defined, including epigenetic …

During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …

Histone modifications are key epigenetic regulators that control chromatin structure and
gene transcription, thereby impacting on various important cellular phenotypes. Over the …

Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …

A critical hallmark of aging is cellular senescence, a state of growth arrest and inflammatory
cytokine release in cells, caused by a variety of stresses. Recent work has convincingly …

The aging process is characterized by gradual changes to an organism's macromolecules,
which negatively impacts biological processes. The complex macromolecular structure of …

Aging is a complex process that results in compromised biological functions of the organism
and increased susceptibility to disease and death. Although the molecular basis of aging is …

Epigenetics refers to phenotypic changes caused by mechanisms that are unrelated to
changes in the underlying DNA sequence, most notably chromatin remodeling driven by …