Inactivation and biotransformation of the endogenous cannabinoids anandamide and 2-arachidonoylglycerol

ML Yates, EL Barker - Molecular pharmacology, 2009 - ASPET
The cannabinoid field is currently an active research area. Anandamide (AEA) and 2-
arachidonoylglycerol (2-AG) are the most characterized endogenous cannabinoids (also …

Anandamide and 2-arachidonoylglycerol: pharmacological properties, functional features, and emerging specificities of the two major endocannabinoids

A Luchicchi, M Pistis - Molecular neurobiology, 2012 - Springer
Since the discovery of endocannabinoids and their receptors, two major members of the
endocannabinoid family, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), have been …

Endocannabinoid biosynthesis and inactivation, from simple to complex

GG Muccioli - Drug discovery today, 2010 - Elsevier
Cannabinoid receptors, the primary molecular targets of the endocannabinoid system, are
activated by specific bioactive lipids termed 'endocannabinoids'. These lipid transmitters are …

Cell signaling by endocannabinoids and their congeners: questions of selectivity and other challenges

HHO Schmid, PC Schmid, EV Berdyshev - Chemistry and physics of lipids, 2002 - Elsevier
The major endocannabinoids, anandamide (N-arachidonoylethanolamide, 20: 4n− 6 N-
acylethanolamine) and 2-arachidonoylglycerol (2-AG) are structurally and functionally …

Endocannabinoids and their actions

M Maccarrone, A Finazzi-Agró - 2002 - Elsevier
Endocannabinoids are a new class of lipid mediators, which includes amides and esters of
long-chain polyunsaturated fatty acids. Anandamide (I) and 2-arachidonoylglycerol (II) are …

More surprises lying ahead. The endocannabinoids keep us guessing

D Piomelli - Neuropharmacology, 2014 - Elsevier
The objective of this review is to point out some important facts that we don't know about
endogenous cannabinoids—lipid-derived signaling molecules that activate CB 1 …

Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown

EA Placzek, Y Okamoto, N Ueda, EL Barker - Neuropharmacology, 2008 - Elsevier
Anandamide (AEA) and 2-arachidonyl glycerol (2-AG), endogenous ligands for the CB1 and
CB2 cannabinoid receptors, are referred to as endocannabinoids because they mimic the …

Methylation and acetylation of 15-hydroxyanandamide modulate its interaction with the endocannabinoid system

D Amadio, F Fezza, G Catanzaro, O Incani… - Biochimie, 2010 - Elsevier
The biological activity of endocannabinoids like anandamide (AEA) and 2-
arachidonoylglycerol (2-AG) is subjected in vivo to a “metabolic control”, exerted mainly by …

Endocannabinoids: synthesis and degradation

V Di Marzo - Reviews of Physiology Biochemistry and …, 2008 - Springer
Endocannabinoids were defined in 1995 as endogenous agonists of cannabinoid receptors,
ie of the G protein-coupled receptors for cannabis's psychoactive principle, Δ 9 …

Endocannabinoid-based therapies

D Piomelli, A Mabou Tagne - Annual Review of Pharmacology …, 2022 - annualreviews.org
The endocannabinoids are lipid-derived messengers that play a diversity of regulatory roles
in mammalian physiology. Dysfunctions in their activity have been implicated in various …