[HTML][HTML] Azithromycin in COVID-19 patients: pharmacological mechanism, clinical evidence and prescribing guidelines

J Sultana, PM Cutroneo, S Crisafulli, G Puglisi… - Drug safety, 2020 - Springer
The global COVID-19 pandemic has led to a race to find medications that can improve the
prognosis of the disease. Azithromycin, in association with hydroxychloroquine or …

Azithromycin in the treatment of COVID-19: a review

D Echeverría-Esnal, C Martin-Ontiyuelo… - Expert review of anti …, 2021 - Taylor & Francis
Introduction SARS-CoV-2 is a novel virus that causes coronavirus disease-19 (COVID-19).
Antiviral and immunomodulatory agents have been proposed as potential treatments …

Should azithromycin be used to treat COVID-19? A rapid review

K Gbinigie, K Frie - BJGP open, 2020 - bjgpopen.org
Background There are no established effective treatments for COVID-19. While novel drugs
are being developed, azithromycin has been identified as a candidate treatment in the …

Clinical pharmacology perspectives on the antiviral activity of azithromycin and use in COVID‐19

B Damle, M Vourvahis, E Wang… - Clinical …, 2020 - Wiley Online Library
Azithromycin (AZ) is a broad‐spectrum macrolide antibiotic with a long half‐life and a large
volume of distribution. It is primarily used for the treatment of respiratory, enteric, and …

Safety and effectiveness of azithromycin in patients with COVID-19: an open-label randomised trial

E Sekhavati, F Jafari, SA SeyedAlinaghi… - International journal of …, 2020 - Elsevier
As no specific pharmacological treatment has been validated for use in coronavirus disease
2019 (COVID-19), we aimed to assess the effectiveness of azithromycin (AZM) in these …

Efficacy and safety of azithromycin in Covid‐19 patients: A systematic review and meta‐analysis of randomized clinical trials

AM Kamel, MSA Monem, NA Sharaf… - Reviews in medical …, 2022 - Wiley Online Library
Azithromycin (AZM) is commonly used in Covid‐19 patients based on low‐quality evidence,
increasing the risk of developing adverse events and antimicrobial resistance. The current …

Rationale for azithromycin in COVID-19: an overview of existing evidence

I Gyselinck, W Janssens… - BMJ Open …, 2021 - bmjopenrespres.bmj.com
Azithromycin has rapidly been adopted as a repurposed drug for the treatment of COVID-19,
despite the lack of high-quality evidence. In this review, we critically appraise the current …

[HTML][HTML] Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

E Abaleke, M Abbas, S Abbasi, A Abbott, A Abdelaziz… - The Lancet, 2021 - thelancet.com
Background Azithromycin has been proposed as a treatment for COVID-19 on the basis of
its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin …

Macrolides and viral infections: focus on azithromycin in COVID-19 pathology

A Pani, M Lauriola, A Romandini… - International journal of …, 2020 - Elsevier
The emergence of the new COVID-19 virus is proving to be a challenge in seeking effective
therapies. Since the most severe clinical manifestation of COVID-19 appears to be a severe …

[HTML][HTML] Azithromycin and hydroxychloroquine in hospitalised patients with confirmed COVID-19: a randomised double-blinded placebo-controlled trial

P Sivapalan, CS Ulrik, TS Lapperre… - European …, 2022 - Eur Respiratory Soc
Background Combining the antibiotic azithromycin and hydroxychloroquine induces airway
immunomodulatory effects, with the latter also having in vitro antiviral properties. This may …