Antibiotic resistance, and the emergence of pan-resistant clinical isolates, seriously
threatens our capability to treat bacterial diseases, including potentially deadly hospital …

The increasing incidence and prevalence of multi-drug resistance (MDR) among
contemporary Gram-negative bacteria represents a significant threat to human health. Since …

The β-lactams have a central place in the antibacterial armamentarium, but the increasing
resistance to these drugs, especially among Gram-negative bacteria, is becoming one of the …

Antimicrobial resistance constitutes one of the major threats regarding pathogenic
microorganisms. Gramnegative pathogens, such as Enterobacteriaceae (specially those …

Importance of the field: β-Lactam antibiotics are among the most frequently prescribed
antibiotics used to treat bacterial infections. However, their utility is being threatened by the …

Since the introduction of penicillin, β-lactam antibiotics have been the antimicrobial agents
of choice. Unfortunately, the efficacy of these life-saving antibiotics is significantly threatened …

The use of successive generations of β-lactams has selected successive generations of β-
lactamases including CTX-M ESBLs, AmpC β-lactamases, and KPC carbapenamases in …

As the incidence of Gram-negative bacterial infections for which few effective treatments
remain increases, so does the contribution of drug-hydrolyzing β-lactamase enzymes to this …

β-Lactams are the most widely used class of antibiotics. Since the discovery of
benzylpenicillin in the 1920s, thousands of new penicillin derivatives and related β-lactam …

β-Lactamase evolution presents to the infectious disease community a major challenge in
the treatment of infections caused by multidrug-resistant gram-negative bacteria. Because …