Self‐assembled, biodegradable materials that embed fragile, soluble, or insoluble
compounds of therapeutic interest have potential use as drug delivery systems. The bead …

To overcome the low efficiency and cytotoxicity associated with most non-viral DNA delivery
systems we developed a purely peptidic self-assembling system that is able to entrap single …

Peptide amphiphiles (PAs), consisting of a hydrophobic alkyl chain covalently bound to a
hydrophilic peptide sequence, possess a versatile molecular design due to their combined …

In this study, oligopeptide amphiphile containing three blocks of amino acids, Ac-(AF) 6-H5-
K15-NH2 (FA32), were synthesized and evaluated as carriers for co-delivery of drug and …

Ever more emerging combined treatments exploiting synergistic effects of drug combinations
demand smart, responsive codelivery carriers to reveal their full potential. In this study, a …

In this paper, the peptide amphiphiles (PA) which consists of RGDSEEEEEEEEEEK as pH-
sensitive segment and stearic acid as hydrophobic segment named RGDS-E10-Lys (C18) …

The safe and efficient delivery of nucleic acids including DNA, mRNA, siRNA, and miRNA
into targeted cells is critical for gene therapy. Currently, viral gene vectors are very popular …

In this study, we designed and fabricated self-assembly nanospheres, which consisted of a
P45 peptide and doxorubicin (Dox). P45 is a hybrid peptide composed of an Arg-Gly-Asp …

In spite of the great potential of nucleic acids as therapeutic agents, the clinical application of
nucleic acid therapeutics requires the development of effective systemic delivery strategies …

An acid-responsive amphiphilic peptide that contains KKGRGDS sequence in hydrophilic
head and VVVVVV sequence in hydrophobic tail was designed and prepared. In neutral or …