Aberrant cytokine expression in COVID-19 patients: Associations between cytokines and disease severity

Y Tang, J Sun, H Pan, F Yao, Y Yuan, M Zeng, G Ye… - Cytokine, 2021 - Elsevier
Cytokines play pleiotropic, antagonistic, and collaborative in viral disease. The high
morbidity and mortality of coronavirus disease 2019 (COVID-19) make it a significant threat …

Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients

Y Zhou, B Fu, X Zheng, D Wang, C Zhao… - National Science …, 2020 - academic.oup.com
Pathogenic human coronavirus infections, such as severe acute respiratory syndrome CoV
(SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV), cause high morbidity …

Calming the storm: natural immunosuppressants as adjuvants to target the cytokine storm in COVID-19

AE Peter, BV Sandeep, BG Rao… - Frontiers in …, 2021 - frontiersin.org
The COVID-19 pandemic has caused a global health crisis, with no specific antiviral to treat
the infection and the absence of a suitable vaccine to prevent it. While some individuals …

COVID-19 and the immune response: A multi-phasic approach to the treatment of covid-19

T Sapir, Z Averch, B Lerman, A Bodzin… - International Journal of …, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a viral agent that causes
Coronavirus disease 2019 (COVID-19), a disease that causes flu-like symptoms that, when …

Biomarkers of cytokine storm as red flags for severe and fatal COVID-19 cases: A living systematic review and meta-analysis

AKG Melo, KM Milby, ALMA Caparroz, ACPN Pinto… - PloS one, 2021 - journals.plos.org
Objective To describe the laboratory parameters and biomarkers of the cytokine storm
syndrome associated with severe and fatal COVID-19 cases. Methods A search with …

[HTML][HTML] Immunopathology of Hyperinflammation in COVID-19

JN Gustine, D Jones - The American journal of pathology, 2021 - Elsevier
The rapid spread of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome–coronavirus 2 (SARS-CoV-2), has resulted in an unprecedented …

Interleukin-6, procalcitonin and neutrophil-to-lymphocyte ratio: Potential immune-inflammatory parameters to identify severe and fatal forms of COVID-19

W Sayah, I Berkane, I Guermache, M Sabri, FZ Lakhal… - Cytokine, 2021 - Elsevier
Accumulating evidence supports that the viral-induced hyper-inflammatory immune
response plays a central role in COVID-19 pathogenesis. It might be involved in the …

Inflammation and antiviral immune response associated with severe progression of COVID-19

Q Zhang, Y Meng, K Wang, X Zhang, W Chen… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease-2019 (COVID-19) is a novel respiratory disease induced by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It remains poorly understood how …

Novel coronavirus disease 2019 (COVID-19) and cytokine storms for more effective treatments from an inflammatory pathophysiology

S Yokota, T Miyamae, Y Kuroiwa… - Journal of Clinical …, 2021 - mdpi.com
The Novel Coronavirus Disease 2019 (COVID-19) has swept the world and caused a global
pandemic. SARS-CoV-2 seems to have originated from bats as their reservoir hosts over …

COVID-19: The emerging immunopathological determinants for recovery or death

T Ahmad, R Chaudhuri, MC Joshi… - Frontiers in …, 2020 - frontiersin.org
Hyperactivation of the host immune system during infection by SARS-CoV-2 is the leading
cause of death in COVID-19 patients. It is also evident that patients who develop …