Under normal conditions, the most significant expansion and differentiation of the adult
mammary gland occurs in response to systemic reproductive hormones during pregnancy …

Cells in human milk are an untapped source, as potential “liquid breast biopsies”, of material
for investigating lactation physiology in a non-invasive manner. We used single cell RNA …

Our understanding of the molecular events underpinning the development of mammalian
organ systems has been increasing rapidly in recent years. With the advent of new and …

The mammary gland is a unique tissue and the defining feature of the class Mammalia. It is a
late-evolving epidermal appendage that has the primary function of providing nutrition for …

Characterising the hierarchy of mammary epithelial cells (MECs) and how they are
regulated during adult development is important for understanding how breast cancer …

Human breast milk (hBM) is a dynamic fluid that contains millions of cells, but their identities
and phenotypic properties are poorly understood. We generated and analyzed single-cell …

The mammary epithelium comprises two primary cellular lineages, but the degree of
heterogeneity within these compartments and their lineage relationships during …

The mammary gland undergoes cycles of growth and regeneration throughout reproductive
life, a process that requires mammary stem cells (MaSCs). Whilst recent genetic fate …

The molecular processes underlying human milk production and the effects of mastitic
infection are largely unknown because of limitations in obtaining tissue samples …

Mammary gland development occurs over multiple phases, beginning in the mammalian
embryo and continuing throughout reproductive life. The remarkable morphogenetic …