Druggable targets of SARS-CoV-2 and treatment opportunities for COVID-19

BK Kumar, KVGC Sekhar, S Kunjiappan, J Jamalis… - Bioorganic …, 2020 - Elsevier
COVID-19 caused by the novel SARS-CoV-2 has been declared a pandemic by the WHO is
causing havoc across the entire world. As of May end, about 6 million people have been …

Treating a global health crisis with a dose of synthetic chemistry

MA Hardy, BA Wright, JL Bachman, TB Boit… - 2020 - ACS Publications
The SARS-CoV-2 pandemic has prompted scientists from many disciplines to work
collaboratively toward an effective response. As academic synthetic chemists, we examine …

Bench-to-bedside: Innovation of small molecule anti-SARS-CoV-2 drugs in China

L Yang, Z Wang - European Journal of Medicinal Chemistry, 2023 - Elsevier
The ongoing COVID-19 pandemic has resulted in millions of deaths globally, highlighting
the need to develop potent prophylactic and therapeutic strategies against SARS-CoV-2 …

Small-molecule antiviral agents in ongoing clinical trials for COVID-19

ÇB Apaydın, G Çınar, G Cihan-Üstündağ - Current drug targets, 2021 - ingentaconnect.com
The coronavirus disease 2019 (COVID-19) pandemic, due to the novel severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in December 2019 and has …

Tackling SARS-CoV-2: proposed targets and repurposed drugs

S Joshi, M Joshi, MS Degani - Future medicinal chemistry, 2020 - Future Science
The SARS-CoV-2 pandemic, declared as a global health emergency by the WHO in
February 2020, has currently infected more than 6 million people with fatalities near 371,000 …

[HTML][HTML] Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Discovering drugs to treat coronavirus disease 2019 (COVID-19)

L Dong, S Hu, J Gao - Drug discoveries & therapeutics, 2020 - jstage.jst.go.jp
The SARS-CoV-2 virus emerged in December 2019 and then spread rapidly worldwide,
particularly to China, Japan, and South Korea. Scientists are endeavoring to find antivirals …

[HTML][HTML] The need for speed and efficiency: a brief review of small molecule antivirals for COVID-19

AC Puhl, TR Lane, F Urbina, S Ekins - Frontiers in Drug Discovery, 2022 - frontiersin.org
While we currently have multiple highly effective vaccines approved for use against SARS-
CoV-2 in the USA and other countries, there are far fewer small molecule antivirals …

Research progress on repositioning drugs and specific therapeutic drugs for SARS-CoV-2

S Fan, D Xiao, Y Wang, L Liu, X Zhou… - Future medicinal …, 2020 - Future Science
SARS-CoV-2 has been widely spread around the world and COVID-19 was declared a
global pandemic by the WHO. Limited clinically effective antiviral drugs are available now …

[HTML][HTML] nCOVID-19 pandemic: from molecular pathogenesis to potential investigational therapeutics

MT Kabir, MS Uddin, MF Hossain… - Frontiers in cell and …, 2020 - frontiersin.org
In December 2019, a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-
related epidemic was first observed in Wuhan, China. In 2020, owing to the highly infectious …