[HTML][HTML] COVID-19 therapeutic options under investigation
M Kaddoura, M AlIbrahim, G Hijazi… - Frontiers in …, 2020 - frontiersin.org
Since its emergence in China in December 2019, COVID-19 has quickly spread around the
globe causing a pandemic. Vaccination or the development of herd immunity seems the only …
globe causing a pandemic. Vaccination or the development of herd immunity seems the only …
[HTML][HTML] Mechanism of action of small-molecule agents in ongoing clinical trials for SARS-CoV-2: a review
L Zhao, S Li, W Zhong - Frontiers in Pharmacology, 2022 - frontiersin.org
Since the first reports from December 2019, COVID-19 caused an overwhelming global
pandemic that has affected 223 countries, seriously endangering public health and creating …
pandemic that has affected 223 countries, seriously endangering public health and creating …
[HTML][HTML] COVID-19 drug discovery using intensive approaches
A Asai, M Konno, M Ozaki, C Otsuka… - International journal of …, 2020 - mdpi.com
Since the infectious disease caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) was reported in China during December 2019, the coronavirus disease 2019 …
(SARS-CoV-2) was reported in China during December 2019, the coronavirus disease 2019 …
[HTML][HTML] The history, mechanism, and perspectives of nirmatrelvir (PF-07321332): an orally bioavailable main protease inhibitor used in combination with ritonavir to …
RP Joyce, VW Hu, J Wang - Medicinal Chemistry Research, 2022 - Springer
The rapid development of effective vaccines to combat the SARS-CoV-2 virus has been an
effective counter measure to decrease hospitalization and the mortality rate in many …
effective counter measure to decrease hospitalization and the mortality rate in many …
Drug development and medicinal chemistry efforts toward SARS‐coronavirus and Covid‐19 therapeutics
AK Ghosh, M Brindisi, D Shahabi… - …, 2020 - Wiley Online Library
The COVID‐19 pandemic caused by SARS‐CoV‐2 infection is spreading at an alarming
rate and has created an unprecedented health emergency around the globe. There is no …
rate and has created an unprecedented health emergency around the globe. There is no …
[HTML][HTML] Drug targets for COVID-19 therapeutics: Ongoing global efforts
A Saxena - Journal of biosciences, 2020 - Springer
The current global pandemic COVID-19 caused by the SARS-CoV-2 virus has already
inflicted insurmountable damage both to the human lives and global economy. There is an …
inflicted insurmountable damage both to the human lives and global economy. There is an …
SARS-CoV-2 main protease drug design, assay development, and drug resistance studies
Conspectus SARS-CoV-2 is the etiological pathogen of the COVID-19 pandemic, which led
to more than 6.5 million deaths since the beginning of the outbreak in December 2019. The …
to more than 6.5 million deaths since the beginning of the outbreak in December 2019. The …
[HTML][HTML] Accelerating antiviral drug discovery: lessons from COVID-19
During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and
collaborative drug discovery efforts took place in academia and industry, culminating in …
collaborative drug discovery efforts took place in academia and industry, culminating in …
[HTML][HTML] RdRp inhibitors and COVID-19: Is molnupiravir a good option?
SMR Hashemian, MH Pourhanifeh, MR Hamblin… - Biomedicine & …, 2022 - Elsevier
Rapid changes in the viral genome allow viruses to evade threats posed by the host immune
response or antiviral drugs, and can lead to viral persistence in the host cells. RNA …
response or antiviral drugs, and can lead to viral persistence in the host cells. RNA …
Evolutionary and structural insights about potential SARS-CoV-2 evasion of nirmatrelvir
The US FDA approval of PAXLOVID, a combination therapy of nirmatrelvir and ritonavir has
significantly boosted our morale in fighting the COVID-19 pandemic. Nirmatrelvir is an …
significantly boosted our morale in fighting the COVID-19 pandemic. Nirmatrelvir is an …