[HTML][HTML] Molecular determinants of Ebola virus virulence in mice

H Ebihara, A Takada, D Kobasa, S Jones… - PLoS …, 2006 - journals.plos.org
Zaire ebolavirus (ZEBOV) causes severe hemorrhagic fever in humans and nonhuman
primates, with fatality rates in humans of up to 90%. The molecular basis for the extreme …

[HTML][HTML] Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression

V Wahl-Jensen, S Kurz, F Feldmann… - PLoS neglected …, 2011 - journals.plos.org
Zaire ebolavirus (ZEBOV) infections are associated with high lethality in primates. ZEBOV
primarily targets mononuclear phagocytes, which are activated upon infection and secrete …

Pathogenicity and Virulence of Ebolaviruses with Species-and Variant-specificity

S Yamaoka, H Ebihara - Virulence, 2021 - Taylor & Francis
Ebola virus (EBOV), belonging to the species Zaire ebolavirus in the genus Ebolavirus,
causes a severe febrile illness in humans with case fatality rates (CFRs) up to 90%. While …

In vitro and in vivo characterization of recombinant Ebola viruses expressing enhanced green fluorescent protein

H Ebihara, S Theriault, G Neumann… - The Journal of …, 2007 - academic.oup.com
To facilitate an understanding of the molecular aspects of the pathogenesis of Zaire
ebolavirus (ZEBOV) infection, we generated 2 different recombinant viruses expressing …

[HTML][HTML] The Ebola Virus Glycoprotein Contributes to but Is Not Sufficient for Virulence In Vivo

A Groseth, A Marzi, T Hoenen, A Herwig, D Gardner… - 2012 - journals.plos.org
Among the Ebola viruses most species cause severe hemorrhagic fever in humans;
however, Reston ebolavirus (REBOV) has not been associated with human disease despite …

[HTML][HTML] Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants

K Versteeg, AR Menicucci, C Woolsey, CE Mire… - Scientific reports, 2017 - nature.com
Zaire Ebolavirus (ZEBOV) continues to pose a significant threat to human health as
highlighted by the recent epidemic that originated in West Africa and the ongoing outbreak …

Pathogenesis of experimental Ebola Zaire virus infection in BALB/c mice

TR Gibb, M Bray, TW Geisbert, KE Steele… - Journal of comparative …, 2001 - Elsevier
Guinea-pigs and non-human primates have traditionally been used as animal models for
studying Ebola Zaire virus (EBO-Z) infections. The virus was also recently adapted to the …

Molecular mechanisms of Ebola pathogenesis

A Rivera, I Messaoudi - Journal of Leucocyte Biology, 2016 - academic.oup.com
Abstract Ebola viruses (EBOVs) and Marburg viruses (MARVs) are among the deadliest
human viruses, as highlighted by the recent and widespread Ebola virus outbreak in West …

Ebola virus: new insights into disease aetiopathology and possible therapeutic interventions

TW Geisbert, LE Hensley - Expert reviews in molecular medicine, 2004 - cambridge.org
Ebola virus (EBOV) gained public notoriety in the last decade largely as a consequence of
the highly publicised isolation of a new EBOV species in a suburb of Washington, DC, in …

Ebola virus: unravelling pathogenesis to combat a deadly disease

T Hoenen, A Groseth, D Falzarano… - Trends in molecular …, 2006 - cell.com
Ebola virus (EBOV) causes severe haemorrhagic fever leading to up to 90% lethality.
Increasingly frequent outbreaks and the placement of EBOV in the category A list of potential …