Abstract Background and Aim: Epithelial barrier function is impaired in ulcerative colitis
(UC), but the pathophysiological mechanisms leading to this barrier defect are still far from …

Abstract Background and Aims Studies have shown a decrease in key tight junction (TJ)
proteins such as ZO-1 and occludin in both inflammatory bowel disease (IBD) and …

We intended to see the pattern of TJ protein expression along with ultrastructural changes in
colonic biopsies from patients with Crohn's disease (CD), ulcerative colitis (UC), and …

Background The aim of this study was to investigate the relationship between intestinal
mucosal healing and tight junction (TJ) protein expression in patients with ulcerative colitis …

Background Tight junction (TJ) proteins play a critical role in cellular adhesion, glandular
differentiation, and cellular proliferation. The function of these proteins is compromised in a …

Background: Epithelial barrier function is impaired in Crohn's disease. Aim: To define the
underlying cellular mechanisms with special attention to tight junctions. Methods: Biopsy …

A key feature of inflammatory bowel disease (IBD) is disruption of the intestinal epithelial
barrier by unknown mechanisms. Integrity of the epithelial barrier is determined by an apical …

Claudin proteins comprise a recently described family of tight junction proteins that
differentially regulate paracellular permeability. Since other tight junction proteins show …

Background. Claudins, being part of the tight junction protein family, partially determine the
integrity and paracellular permeability of the intestinal epithelium. The aim of this study was …

Patients with inflammatory bowel disease (IBD) are at increased risk of developing
colorectal adenocarcinoma. The factors that result in IBD-associated carcinogenesis are not …