Self‐controlled observational study designs, such as the case–crossover design and the self‐
controlled case series, are reviewed, and their respective rationale, strengths and limitations …

Background Observational studies are widely used in pharmacoepidemiology. Several
designs can be used, in particular self-controlled designs (case-crossover and self …

Purpose Consensus is needed on conceptual foundations, terminology and relationships
among the various self‐controlled “trigger” study designs that control for time‐invariant …

Background Despite the frequent use of self-controlled methods in
pharmacoepidemiological studies, the factors that may bias the estimates from these …

The self controlled case series (SCCS) method is an epidemiological study design for which
individuals act as their own control—ie, comparisons are made within individuals. Hence …

Standard cohort and case–control designs are suited to the study of cumulative effects of
chronic exposures, but they are prone to confounding by indication. Case–crossover and …

Background Case-only designs have been used since late 1980's. In these, as opposed to
case-control or cohort studies for instance, only cases are required and are self-controlled …

This article is the first of a three‐part series intended to enhance clinical pharmacists'
understanding of methods frequently used in epidemiologic research and their applications …

Self-Controlled Case Series Studies: A Modelling Guide with R provides the first
comprehensive account of the self-controlled case series (SCCS) method, a statistical …

Purpose To assess case‐only designs for surveillance with administrative databases.
Methods We reviewed literature on two designs that are observational analogs to crossover …