To investigate combined effect of the anticancer drug cisplatin (CP) and the opiate analgesic
morphine (MOR) on liver, rats were administered MOR (10 mg/kg/day ip for 10 days), with or …

Abstract Background/Aims: Multidrug resistance protein 2 (Abcb4) gene knockout mice
(Mdr2−/−) lack phosphatidylcholine (PC) excretion into bile and spontaneously develop …

The present study assessed the therapeutic potential of omeprazole (OME), the most
commonly prescribed proton pump inhibitor (PPI) used to treat gastroesophageal …

Objective: Acetaminophen (APAP) overdose contributes to liver damage through modulation
of pro-apoptotic processing. This study evaluated the involvement of caspase/Bax factors in …

Method HepaRG cells were exposed to CPZ concentrations of 25, 50 and 100 μM for 24 h.
Cell viability was assessed by ATP-depletion assay (CellTiter-Glo). Assessment of …

This study investigated alterations in the function and expression of P-glycoprotein (P-GP),
breast cancer resistance protein (BCRP), and multidrug resistance-associated protein 2 …

Fentanyl, a potent opioid analgesic that is used to treat cancer pain, is commonly
administered with paclitaxel in advanced tumors. However, the effect of fentanyl on the …

Previous studies suggest that P‐glycoprotein (P‐gp) modulates the PK/PD of many
compounds including opioid agonists and chemotherapeutic agents. The objective of this …

P-glycoprotein (or P-gp1, ABCB1) expression in tumor cells is causative of multidrug
resistance through the active efflux of drugs across the cell membrane. However, the over …

In the present study, we aimed to investigate the underlying mechanism of acetaminophen
(APAP)-induced hepatotoxicity by measuring the expression levels of liver transporters and …