RNA binding proteins (RBPs) have recently emerged as important post-transcriptional gene
expression regulators in both normal development and disease. RBPs influence the fate of …

Posttranscriptional regulation of mRNA is a powerful and tightly controlled process in which
cells command the integrity, diversity, and abundance of their protein products. RNA-binding …

RNA-binding proteins (RBPs) play a crucial role in cellular physiology by regulating RNA
processing, translation, and turnover. In neoplasms, RBP support of cancer-relevant …

Acute myeloid leukemia (AML) is a group of genetically complex and heterogeneous
invasive hematological malignancies with a low 5-year overall survival rate of 30%, which …

RNA-binding proteins (RBPs) regulate fundamental processes, such as differentiation and
self-renewal, by enabling the dynamic control of protein abundance or isoforms or through …

Acute leukemias are genetic diseases caused by translocations or mutations, which
dysregulate hematopoiesis towards malignant transformation. However, the molecular mode …

Hematological malignancies comprise a plethora of different neoplasms, such as leukemia,
lymphoma, and myeloma, plus a myriad of dysplasia, such as myelodysplastic syndromes or …

Posttranscriptional control of gene expression is important for defining both normal and
pathological cellular phenotypes. In vitro, RNA-binding proteins (RBPs) have recently been …

Despite growing awareness of the biologic features underlying MLL-rearranged leukemia,
targeted therapies for this leukemia have remained elusive and clinical outcomes remain …

RNA-binding proteins (RBPs) are essential modulators of transcription and translation
frequently dysregulated in cancer. We systematically interrogated RBP dependencies in …