Microbiota as therapeutic targets

RJ Xavier - Digestive Diseases, 2016 - karger.com
Background: Inflammatory bowel disease (IBD) represents a family of diseases including
Crohn's disease and ulcerative colitis. IBD has garnered significant attention in recent years …

[HTML][HTML] The intricate link among gut “immunological niche,” microbiota, and xenobiotics in intestinal pathology

D Pagliari, G Gambassi, CA Piccirillo… - Mediators of …, 2017 - hindawi.com
Inflammatory bowel diseases (IBDs) are diseases characterized by various degrees of
inflammation involving the gastrointestinal tract. Ulcerative colitis and Crohn's disease are …

[HTML][HTML] Intestinal homeostasis and disease: a complex partnership between immune cells, non-immune cells, and the microbiome

M De la Fuente, TT MacDonald… - Frontiers in …, 2019 - frontiersin.org
Risk factors that predispose an individual to loss of gut homeostasis include genetic variants
and mutations, dysbiosis, immune dysregulation, and alterations in epithelial barrier function …

Microbes, intestinal inflammation and probiotics

MW Khan, AA Kale, P Bere, S Vajjala… - Expert Review of …, 2012 - Taylor & Francis
Inflammatory bowel disease (IBD) is known for causing disturbed homeostatic balance
among the intestinal immune compartment, epithelium and microbiota. Owing to the …

Inflammatory bowel disease: between genetics and microbiota

N Younis, R Zarif, R Mahfouz - Molecular biology reports, 2020 - Springer
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease that can
involve any part of the gastrointestinal tract. It includes two main disorders: Crohn's disease …

[HTML][HTML] Regulatory immune cells in regulation of intestinal inflammatory response to microbiota

M Sun, C He, Y Cong, Z Liu - Mucosal immunology, 2015 - Elsevier
The intestinal lumen harbors nearly 100 trillion commensal bacteria that exert crucial
function for health. An elaborate balance between immune responses and tolerance to …

Microbiota regulation of inflammatory bowel disease

HL Evans-Marin, Y Cong - Inflammation & Allergy-Drug …, 2014 - ingentaconnect.com
The intestines harbor over trillions of commensal bacteria, which co-evolve and form a
mutualistic relationship with the host, with microbial-host interaction shaping immune …

Interactions between intestinal microbiota and innate immune system in pediatric inflammatory bowel disease

S Cucchiara, L Stronati, M Aloi - Journal of clinical …, 2012 - journals.lww.com
Inflammatory bowel disease (IBD) is the result of an altered immune homeostasis within the
intestinal mucosa against the gut microbiota, leading to chronic inflammation in genetically …

[PDF][PDF] Inflammatory bowel disease as a model for translating the microbiome

C Huttenhower, AD Kostic, RJ Xavier - Immunity, 2014 - cell.com
The inflammatory bowel diseases (IBDs) are among the most closely studied chronic
inflammatory disorders that involve environmental, host genetic, and commensal microbial …

Inflammatory bowel disease, past, present and future: lessons from animal models

A Mizoguchi, E Mizoguchi - Journal of gastroenterology, 2008 - Springer
Accumulating data from animal models indicate that Inflammatory bowel disease (IBD) is
mediated by a much more complicated mechanism than previously predicted. For example …