Activation of activator protein 1 (AP-1) and nuclear factor κB (NFκB)–dependent transcription
is required for tumor promotion in cell culture models and transgenic mice. Dominant …

We previously reported that induced activator protein‐1 (AP‐1) transcriptional activity
appears to be required for tumor promoter–induced transformation in mouse epidermal JB6 …

Neoplastically transformed mouse and human keratinocytes elevate transactivation of both
activator protein 1 (AP‐1) and nuclear factor κB (NFκB) transcription factors. The present …

The transcription factor AP-1 (activator protein-1) regulates a number of genes that drive
tumor promotion and progression. While basal levels of AP-1 activity are important for …

Activator protein-1 (AP-1) is a transcription factor that consists of either a Jun-Jun
homodimer or a Jun-Fos heterodimer. Transactivation of AP-1 is required for tumor promoter …

AP-1 transactivation appears to be required for mouse JB6 cell neoplastic transformation
induced by the tumor promoter TPA or epidermal growth factor (EGF). Exposure to AP-1 …

Activation of the transcription factor AP-1 (activator protein-1) is required for tumor promotion
and maintenance of malignant phenotype. A number of AP-1-regulated genes that play a …

Okadaic acid (OA) is a prototypical non-phorbol ester skin tumor-promoting agent that works
by inhibiting protein phosphatases, leading to an increase in protein phosphorylation …

Expression of the human papillomavirus (HPV) type 16 E6 and E7 gene products is a risk
factor for human cervical carcinogenesis as well as skin and oral carcinogenesis …

Tumour necrosis factor-α (TNF-α) deficient mice (TNF-α−/− mice) are resistant to skin
carcinogenesis. Cellular signalling via the transcription factor complex AP-1 is thought to …