Plasmacytoid predendritic cells or type 1 interferon (IFN)-producing cells (IPCs) have
recently been identified in mice. Although culture systems giving rise to different murine …

The putative counterparts of human plasmacytoid pre-dendritic cells (pDCs) have been
described in vivo in mouse models and very recently in an in vitro culture system. In this …

Flt3 ligand (Flt3L) is a growth factor for hemopoietic progenitors and can promote the
expansion of both conventional dendritic cells (DCs) and plasmacytoid predendritic cells (p …

Interferon α/β plays an important role in the first-line defense against viral infections and can
modulate cytokine responses by T-helper cells. Type 1 interferons (IFNs) are clinically …

Murine dendritic cells (DCs) can be classified into at least 2 subsets,“myeloid-
related”(CD11bbright, CD8α−) and “lymphoid-related”(CD11bdull, CD8α+), but the absolute …

The dendritic cell system contains conventional dendritic cells (DCs) and plasmacytoid pre-
dendritic cells (pDCs). Both DCs and pDCs are bone marrow derived cells. Although the …

The development of functionally specialized subtypes of dendritic cells (DCs) can be
modeled through the culture of bone marrow with the ligand for the cytokine receptor Flt3 …

In this issue, two papers describe the in vitro generation of an intriguing subset of human
dendritic cells (DCs), the plasmacytoid DCs (pDCs [1, 2]). For nearly 20 years after their …

We have recently shown that Flt3 ligand administration dramatically increases dendritic cell
(DC) numbers in various mouse tissues. This has enabled the identification of distinct …

We provide phenotypic and functional evidence of premonocytoid dendritic cells (DCs) and
preplasmacytoid DCs in blood and of corresponding DC subsets in secondary lymphoid …