The interleukin-1 family consists of three structurally related polypeptides. The first two are
interleukin-1α and interleukin-1β, each of which has a broad spectrum of both beneficial and …

Interleukin-1 is a highly active proinflammatory cytokine that causes not only fever, anorexia,
and other constitutional symptoms but also tissue damage and remodeling. All these effects …

The therapeutic advantage of reducing the activity of interleukin 1 (IL-1) resides in
preventing its deleterious biological effects without interfering with homeostasis. As such …

Interleukin-6, an inflammatory cytokine, is characterized by pleiotropy and redundancy of
action. Apart from its hematologic, immune, and hepatic effects, it has many endocrine and …

Interleukins are polypeptides that act on leukocytes and other tissue targets. Interleukin-1,
produced by macrophages and other cells, activates lymphocytes and also induces several …

Publisher Summary Interleukin-1 (IL-1) and tumor necrosis factor (TNF) participate in self-
augmentation induction mechanisms. Recombinant human IL-1 and TNF are each capable …

Abstract Interleukin-1 (IL-1) represents a family of polypeptides with a wide range of
biological activities. At least two dissimilar gene products have been cloned; there are …

Abstract Interleukin-1 (IL-1) is a cytokine with multiple biologic activities. Since its first
description in 1972, significant work has been done, leading to an understanding of the …

Ten years ago the cloning of two interleukin‐1 molecules (IL‐1α and IL‐1β) resolved the
question of whether a single polypeptide could evoke a wide variety of biological effects …

Publisher Summary This chapter discusses the historical background of interleukin-1 (IL-1)
inhibitors and the experimental work that led to the initial identification of the molecule …