Renin is a crucial enzyme involved in the regulation of blood pressure and electrolyte
balance. It has been shown that renin expressing cells arise from the Foxd1+ stromal …

Background: Normal kidney development requires coordinated interactions between
multiple progenitor cells. Foxd1+ cells are critical for normal nephrogenesis and their …

Rationale Renin cells are essential for survival. They control the morphogenesis of the
kidney arterioles, and the composition and volume of our extracellular fluid, arterial blood …

Podocytes are terminally differentiated cells with an elaborate cytoskeleton and are critical
components of the glomerular barrier. We identified a bHLH transcription factor, Tcf21, that is …

Kidneys are highly vascularized and contain many distinct vascular beds. However, the
origins of renal endothelial cells and roles of the developing endothelia in the formation of …

Background The mammalian kidney develops through reciprocal inductive signals between
the metanephric mesenchyme and ureteric bud. Transcription factor 21 (Tcf21) is highly …

Kidneys are highly vascularized and contain many distinct vascular beds. However, the 24
origins of renal endothelial cells and roles of the developing endothelia in the formation 25 …

Nephron development proceeds with reciprocal interactions among three layers: nephron
progenitors (NPs), ureteric buds and stromal progenitors (SPs). We found that Foxc1 and …

Tbx18 has been shown to be essential for ureteral development. However, it remains
unclear whether it plays a direct role in kidney development. Here we addressed this by …

Background Kidney formation requires coordinated interactions between multiple cell types.
Input from the interstitial progenitor cells is implicated in multiple aspects of kidney …