Coronavirus disease 2019 (COVID-19) pandemic, a global health threat, was caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 papain …

In the absence of an approved vaccine, developing effective severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) antivirals is essential to tackle the current pandemic …

Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), the pathogen of the
Coronavirus disease-19 (COVID-19), is still devastating the world causing significant chaos …

Abstract SARS-CoV-2 papain-like protease (PLpro) covers multiple functions. Beside the
cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the …

The papain-like protease (PLpro) of SARS-CoV-2 is a validated antiviral drug target.
Through a fluorescence resonance energy transfer-based high-throughput screening and …

While vaccines remain at the forefront of global healthcare responses, pioneering
therapeutics against SARS-CoV-2 are expected to fill the gaps for waning immunity. Rapid …

As the pathogen of COVID‐19, SARS‐CoV‐2 encodes two essential cysteine proteases that
process the pathogen's two large polypeptide products pp1a and pp1ab in the human cell …

SARS-CoV-2 is the pathogen responsible for the COVID-19 pandemic. The SARS-CoV-2
papain-like cysteine protease (PLpro) has been implicated in playing important roles in virus …

COVID-19 is a disease caused by SARS-CoV-2, which has led to more than 4 million deaths
worldwide. As a result, there is a worldwide effort to develop specific drugs for targeting …

SARS-CoV-2 encodes two viral cysteine proteases, the main protease (Mpro) and the
papain-like protease (PLpro), both of which are validated antiviral drug targets. PLpro is …