The genetics of depression: successful genome-wide association studies introduce new challenges

J Ormel, CA Hartman, H Snieder - Translational psychiatry, 2019 - nature.com
The recent successful genome-wide association studies (GWASs) for depression have
yielded more than 80 replicated loci and brought back the excitement that had evaporated …

Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies

N Cai, KW Choi, EI Fried - Human molecular genetics, 2020 - academic.oup.com
With progress in genome-wide association studies of depression, from identifying zero hits
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …

Genetics of depression: progress at last

N Mullins, CM Lewis - Current psychiatry reports, 2017 - Springer
Abstract Purpose of Review We will describe the success of recent genome-wide
association studies that identify genetic variants associated with depression and outline the …

[PDF][PDF] Uncovering the genetic architecture of major depression

AM McIntosh, PF Sullivan, CM Lewis - Neuron, 2019 - cell.com
There have been several recent studies addressing the genetic architecture of depression.
This review serves to take stock of what is known now about the genetics of depression, how …

The current state of play on the molecular genetics of depression

S Cohen-Woods, IW Craig, P McGuffin - Psychological medicine, 2013 - cambridge.org
BackgroundIt has been well established that both genes and non-shared environment
contribute substantially to the underlying aetiology of major depressive disorder (MDD). A …

An analysis of two genome-wide association meta-analyses identifies a new locus for broad depression phenotype

N Direk, S Williams, JA Smith, S Ripke, T Air… - Biological …, 2017 - Elsevier
Background The genetics of depression has been explored in genome-wide association
studies that focused on either major depressive disorder or depressive symptoms with …

The genetics of depression: a review

DF Levinson - Biological psychiatry, 2006 - Elsevier
Major depressive disorder (MDD) is common and moderately heritable. Recurrence and
early age at onset characterize cases with the greatest familial risk. Major depressive …

A genome-wide association study of depressive symptoms

K Hek, A Demirkan, J Lahti, A Terracciano, A Teumer… - Biological …, 2013 - Elsevier
BACKGROUND: Depression is a heritable trait that exists on a continuum of varying severity
and duration. Yet, the search for genetic variants associated with depression has had few …

The genetic basis of major depressive disorder

J Flint - Molecular psychiatry, 2023 - nature.com
The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

NR Wray, S Ripke, M Mattheisen, M Trzaskowski… - Nature …, 2018 - nature.com
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …