An iterative identification procedure for dynamic modeling of biochemical networks

E Balsa-Canto, AA Alonso, JR Banga - BMC systems biology, 2010 - Springer
Background Mathematical models provide abstract representations of the information
gained from experimental observations on the structure and function of a particular …

[PDF][PDF] Identifiability of large nonlinear biochemical networks

AF Villaverde, A Barreiro - MATCH Commun. Math. Comput …, 2016 - researchgate.net
Dynamic models formulated as a set of ordinary differential equations provide a detailed
description of the time-evolution of a system. Such models of (bio) chemical reaction …

Recent developments in parameter estimation and structure identification of biochemical and genomic systems

IC Chou, EO Voit - Mathematical biosciences, 2009 - Elsevier
The organization, regulation and dynamical responses of biological systems are in many
cases too complex to allow intuitive predictions and require the support of mathematical …

Systems biology: parameter estimation for biochemical models

M Ashyraliyev, Y Fomekong‐Nanfack… - The FEBS …, 2009 - Wiley Online Library
Mathematical models of biological processes have various applications: to assist in
understanding the functioning of a system, to simulate experiments before actually …

Inference of complex biological networks: distinguishability issues and optimization-based solutions

G Szederkényi, JR Banga, AA Alonso - BMC systems biology, 2011 - Springer
Background The inference of biological networks from high-throughput data has received
huge attention during the last decade and can be considered an important problem class in …

Systems biology: model based evaluation and comparison of potential explanations for given biological data

G Cedersund, J Roll - The FEBS journal, 2009 - Wiley Online Library
Systems biology and its usage of mathematical modeling to analyse biological data is
rapidly becoming an established approach to biology. A crucial advantage of this approach …

On the relationship between sloppiness and identifiability

OT Chis, AF Villaverde, JR Banga… - Mathematical …, 2016 - Elsevier
Dynamic models of biochemical networks are often formulated as sets of non-linear ordinary
differential equations, whose states are the concentrations or abundances of the network …

Insights into the behaviour of systems biology models from dynamic sensitivity and identifiability analysis: a case study of an NF-κB signalling pathway

H Yue, M Brown, J Knowles, H Wang… - Molecular …, 2006 - pubs.rsc.org
Mathematical modelling offers a variety of useful techniques to help in understanding the
intrinsic behaviour of complex signal transduction networks. From the system engineering …

Iterative approach to model identification of biological networks

KG Gadkar, R Gunawan, FJ Doyle - BMC bioinformatics, 2005 - Springer
Background Recent advances in molecular biology techniques provide an opportunity for
developing detailed mathematical models of biological processes. An iterative scheme is …

Set-base dynamical parameter estimation and model invalidation for biochemical reaction networks

P Rumschinski, S Borchers, S Bosio, R Weismantel… - BMC systems …, 2010 - Springer
Background Mathematical modeling and analysis have become, for the study of biological
and cellular processes, an important complement to experimental research. However, the …