[HTML][HTML] Structural perspectives of the CYP3A family and their small molecule modulators in drug metabolism
Cytochrome P450 (CYP) enzymes function to catalyze a wide range of reactions, many of
which are critically important for drug response. Members of the human cytochrome P450 3A …
which are critically important for drug response. Members of the human cytochrome P450 3A …
[HTML][HTML] Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism
AA Walsh, GD Szklarz, EE Scott - Journal of Biological Chemistry, 2013 - ASBMB
Cytochrome P450 (CYP) 1A1 is an extrahepatic monooxygenase involved in the metabolism
of endogenous substrates and drugs, as well as the activation of certain toxins and …
of endogenous substrates and drugs, as well as the activation of certain toxins and …
Structural basis for ligand promiscuity in cytochrome P450 3A4
M Ekroos, T Sjögren - … of the National Academy of Sciences, 2006 - National Acad Sciences
Cytochrome P450 (CYP) 3A4 is the most promiscuous of the human CYP enzymes and
contributes to the metabolism of≈ 50% of marketed drugs. It is also the isoform most often …
contributes to the metabolism of≈ 50% of marketed drugs. It is also the isoform most often …
[HTML][HTML] Cytochrome P450 enzymes and drug metabolism in humans
M Zhao, J Ma, M Li, Y Zhang, B Jiang, X Zhao… - International journal of …, 2021 - mdpi.com
Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play
important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In …
important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In …
In vitro and pharmacophore insights into CYP3A enzymes
S Ekins, DM Stresser, JA Williams - Trends in pharmacological sciences, 2003 - cell.com
Abstract The cytochrome P450 3A (CYP3A) enzymes have a major role in the metabolism of
drugs in humans. Their wide substrate specificity and induction by a vast array of structurally …
drugs in humans. Their wide substrate specificity and induction by a vast array of structurally …
Mechanisms and significance of inhibitory drug interactions involving cytochrome P450 enzymes
M Murray - International Journal of Molecular Medicine, 1999 - spandidos-publications.com
The cytochrome P450 (CYP) superfamily of enzymes are catalytically competent toward an
unusually diverse array of lipophilic chemicals. The major microsomal CYP in human liver …
unusually diverse array of lipophilic chemicals. The major microsomal CYP in human liver …
Unraveling the structural basis of selective inhibition of human cytochrome P450 3A5
J Wang, CD Buchman, J Seetharaman… - Journal of the …, 2021 - ACS Publications
The human cytochrome P450 (CYP) CYP3A4 and CYP3A5 enzymes metabolize more than
one-half of marketed drugs. They share high structural and substrate similarity and are often …
one-half of marketed drugs. They share high structural and substrate similarity and are often …
Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4
SF Zhou - Current drug metabolism, 2008 - ingentaconnect.com
Human cytochrome P450 (CYP) 3A4 is the most abundant hepatic and intestinal phase I
enzyme that metabolizes approximately 50% marketed drugs. The crystal structure of bound …
enzyme that metabolizes approximately 50% marketed drugs. The crystal structure of bound …
Structural insights into understudied human cytochrome P450 enzymes
Human cytochrome P450 (CYP) enzymes are widely known for their pivotal role in the
metabolism of drugs and other xenobiotics as well as of endogenous chemicals. In addition …
metabolism of drugs and other xenobiotics as well as of endogenous chemicals. In addition …
Cytochrome P450 structure–function: insights from molecular dynamics simulations
Abstract Cytochrome P450 (CYP) family 1, 2, and 3 enzymes play an essential role in the
metabolic clearance and detoxification of a myriad of structurally and chemically diverse …
metabolic clearance and detoxification of a myriad of structurally and chemically diverse …