The human melanocyte is continuously exposed to intrinsic and extrinsic sources of reactive
biochemical species, but is finely tuned via the intrinsic anti‐oxidant and radical properties of …

Epidermal melanocytes are particularly vulnerable to oxidative stress owing to the pro-
oxidant state generated during melanin synthesis, and to the intrinsic antioxidant defenses …

The high number of somatic mutations in the melanoma genome associated with cumulative
ultra violet (UV) exposure has rendered it one of the most difficult of cancers to treat. With …

Cutaneous melanoma is the most aggressive type of skin cancer. Although cutaneous
melanoma accounts for a minority of all types of skin cancer, it causes the greatest number …

Melanocytes and melanoma cells contain melanin, a complex polymer that modulates redox
changes in these cells. Relative intracellular hydrogen peroxide levels measured by …

Most melanomas occur on the skin, but a small percentage of these life‐threatening cancers
affect other parts of the body, such as the eye and mucous membranes, including the mouth …

Melanins are ubiquitous catecholic pigments, formed in organelles called melanosomes
within melanocytes, the function of which is to protect skin against harmful effects of UV …

Melanin synthesis is an oxygen‐dependent process that acts as a potential source of
reactive oxygen species (ROS) inside pigment‐forming cells. The synthesis of the lighter …

Several hypotheses have explicitly implicated the role of an altered redox status of melanin
in the aetiology of melanoma and macular degeneration. The balance between the intrinsic …

Solar ultraviolet radiation (UV) is a major environmental factor that dramatically alters the
homeostasis of the skin as an organ by affecting the survival, proliferation and differentiation …