H3K9 trimethylation controls oncogenic signaling and the malignant state in mantle cell lymphoma

A Hajmirza - 2017 - theses.hal.science
Mantle cell lymphoma (MCL) is an aggressive lymphoid cancer characterised by iterative
clinical relapses and short survival. MCL displays complex genetics and hallmarks of …

Genomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma

VV Leshchenko, PY Kuo, R Shaknovich… - Blood, The Journal …, 2010 - ashpublications.org
Mantle cell lymphoma (MCL) is a mostly incurable malignancy arising from naive B cells
(NBCs) in the mantle zone of lymph nodes. We analyzed genomewide methylation in MCL …

Targeting lysine demethylase 5 (KDM5) in mantle cell lymphoma

D Xu, F Bewicke-Copley, K Close, J Okosun… - Blood Cancer …, 2024 - nature.com
The prognosis of advanced mantle cell lymphoma (MCL) is poor [1]. Analyses of genomic
and epi-genomic landscapes indicate a critical role for the DNA methylome and its interplay …

Mantle cell lymphoma pathogenesis: another turn of the screw to cyclin D1 overexpression

R Albero Gallego - 2017 - diposit.ub.edu
[eng] Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm derived from mature
B cells characterized by the presence of the t (11; 14)(q13; q32) translocation that leads to …

Genome‐wide methylation analyses identify a subset of mantle cell lymphoma with a high number of methylated CpGs and aggressive clinicopathological features

A Enjuanes, R Albero, G Clot, A Navarro… - … journal of cancer, 2013 - Wiley Online Library
Mantle cell lymphoma (MCL) is a B‐cell neoplasm with an aggressive clinical behavior
characterized by the t (11; 14)(q13; q32) and cyclin D1 overexpression. To clarify the …

Identification of methylated genes associated with aggressive clinicopathological features in mantle cell lymphoma

A Enjuanes, V Fernandez, L Hernández, A Navarro… - PLoS …, 2011 - journals.plos.org
Background Mantle cell lymphoma (MCL) is genetically characterized by the t (11; 14)(q13;
q32) translocation and a high number of secondary chromosomal alterations. The …

EHMT2 (G9a) activation in mantle cell lymphoma and its associated DNA methylation and gene expression

J Wang, H Xu, S Ge, C Xue, H Li, X Jing… - Cancer Biology & …, 2021 - pmc.ncbi.nlm.nih.gov
Objective: The function of euchromatic histone-lysine N-methyltransferase 2 (EHMT2) has
been studied in several cancers; however, little is known about its role in mantle cell …

Dynamic changes in gene mutational landscape with preservation of core mutations in mantle cell lymphoma cells

Q Zhang, HY Wang, X Liu, MH Roth, AA Shestov… - Frontiers in …, 2019 - frontiersin.org
While studies have identified a number of mutations in mantle cell lymphoma (MCL), the list
may still be incomplete and contribution to the pathogenesis remains unclear. We analyzed …

Genome-Wide Methylation Analysis of Primary Mantle Cell Lymphomas Identifies Novel Gene Targets for Epigenetic Drug Therapy.

V Leshchenko, PY Kuo, R Shaknovich, T Gellen… - 2009 - ashpublications.org
Abstract Abstract 673 Mantle Cell Lymphoma (MCL) is an aggressive and incurable
malignancy arising from naïve B cells (NBC) in the mantle zone of lymph node follicles …

H3K9me3-Governed Senescence In Tumor Development and Lymphoma Treatment

J Kase, J Dörr, Y Yu, M Milanovic, S Ji… - 2013 - ashpublications.org
Introduction Premature senescence, a terminal cell-cycle arrest condition of viable cells in
response to acute cellular stresses such as oncogenic activation or DNA-damaging …