Exposure of cultured human melanocytes to ultraviolet radiation (UV) results in DNA
damage. In melanoma, UV‐signature mutations resulting from unrepaired photoproducts are …

Epidermal melanocytes are skin cells specialized in melanin production. Activation of the
melanocortin 1 receptor (MC1R) on melanocytes by α-melanocyte–stimulating hormone (α …

Activation of the melanocortin 1 receptor (MC1R) by α‐melanocortin (α‐MSH) stimulates
eumelanin synthesis and enhances repair of ultraviolet radiation (UV)‐induced DNA …

Melanomas occur mainly in sunlight-exposed skin. Xeroderma pigmentosum (XP) patients
have 1,000-fold higher incidence of melanoma, suggesting that sunlight-induced “bulky” …

Melanoma is the deadliest form of skin cancer, with no cure for advanced disease. We
propose a strategy for melanoma prevention based on using analogs of α‐melanocyte …

Exposure to solar UV radiation is the origin of most skin cancers, including deadly
melanomas. Melanomas are quite different from keratinocyte-derived tumours and exhibit a …

Keratinocytes and melanocytes, two cutaneous cell types located within the epidermis, are
the origin of most skin cancers, namely carcinomas and melanomas. These two types of …

Melanin synthesis is an oxygen‐dependent process that acts as a potential source of
reactive oxygen species (ROS) inside pigment‐forming cells. The synthesis of the lighter …

Purpose: UV radiation is the major environmental risk factor for melanoma and a potent
inducer of oxidative stress, which is implicated in the pathogenesis of several malignancies …

Constitutive pigmentation determines the response to sun exposure and the risk for
melanoma, an oxidative stress–driven tumor. Using primary cultures of human melanocytes …