Insulin-dependent diabetes mellitus is an autoimmune disease characterized by the
selective destruction of the pancreatic β-cell. The autoimmune response that is ultimately …

Cytokines released by both T lymphocytes and activated macrophages, in particular
interleukin-1 (IL-1), have been implicated as immunological effector molecules that both …

Cytokines have been proposed as inducers of beta-cell damage in human insulin-
dependent diabetes mellitus via the generation of nitric oxide (NO). This concept is mostly …

In this review we propose that the balance between the action of interleukin 1 (IL-1) and its
natural antagonist IL-1ra on the level of the insulin-producing pancreatic β-cell may play a …

Autoimmune diabetes is characterized by the selective destruction of insulin-secreting β-
cells that occurs during an inflammatory reaction in and around pancreatic islets of …

Insulin-dependent diabetes mellitus is an autoimmune disease characterized by the
selective destruction of insulin-secreting β cells found in islets of Langerhans. The …

In pancreatic islets, nitric oxide (NO) produced on exposure to cytokines mediates β-cell
injury leading to diabetes mellitus. On the other hand, l-arginine-derived NO may participate …

Cytokines have been implicated in pancreatic β-cell destruction leading to type 1 diabetes.
In vitro, a combination of γ-interferon (IFN-γ) and interleukin-1 (IL-1) stimulate inducible nitric …

Cytokines have been implicated as immunological effector molecules that induce
dysfunction and destruction of the pancreatic β-cell. The mechanisms of cytokine action on …

Cytokines, released in and around pancreatic islets during insulitis, have been proposed to
participate in beta-cell destruction associated with autoimmune diabetes. In this study we …