The use of endothelial progenitor cells for prevascularized bone tissue engineering

J Rouwkema, PE Westerweel, J de Boer… - … Engineering Part A, 2009 - liebertpub.com
In vitro vascularization is an upcoming strategy to solve the problem of insufficient blood
supply after implantation. Although recent publications show promising results, these studies …

The role of endothelial progenitor cells in prevascularized bone tissue engineering: development of heterogeneous constructs

NE Fedorovich, RT Haverslag, WJA Dhert… - … Engineering Part A, 2010 - liebertpub.com
In vitro prevascularization of bone grafts with endothelial progenitor cells (EPCs) is a
promising strategy to improveimplant survival. In this study we show bone formation in …

Differential analysis of peripheral blood‐and bone marrow‐derived endothelial progenitor cells for enhanced vascularization in bone tissue engineering

AR Amini, CT Laurencin… - Journal of orthopaedic …, 2012 - Wiley Online Library
For tissue engineering applications, effective bone regeneration requires rapid neo‐
vascularization of implanted grafts to ensure the survival of cells in the early post …

Endothelial progenitor cells from peripheral blood support bone regeneration by provoking an angiogenic response

SM Goerke, J Obermeyer, J Plaha, GB Stark… - Microvascular …, 2015 - Elsevier
Neovascularization is crucial for fracture healing and plays an important role in long-time
graft survival in tissue engineering applications. Endothelial progenitor cells (EPCs) can be …

Endothelial cells assemble into a 3-dimensional prevascular network in a bone tissue engineering construct

J Rouwkema, JD Boer, CAV Blitterswijk - Tissue engineering, 2006 - liebertpub.com
To engineer tissues with clinically relevant dimensions, one must overcome the challenge of
rapidly creating functional blood vessels to supply cells with oxygen and nutrients and to …

Pre-vascularization of bone tissue-engineered constructs

MA Brennan, JM Davaine, P Layrolle - Stem cell research & therapy, 2013 - Springer
Vascularization remains one of the primary obstacles in the repair of bone defects. In the
previous issue of Stem Cell Research & Therapy, Pedersen and colleagues show that co …

[HTML][HTML] CD34/CD133 enriched bone marrow progenitor cells promote neovascularization of tissue engineered constructs in vivo

M Herrmann, A Binder, U Menzel, S Zeiter, M Alini… - Stem cell …, 2014 - Elsevier
Vascularization is critical for 3D tissue engineered constructs. In large size implants the
ingrowth of vessels often fails. The purpose of this study was to identify an easily accessible …

[PDF][PDF] Early endothelial progenitor cells as a source of myeloid cells to improve the pre-vascularisation of bone constructs

Y Shi, G Kramer, A Schröder, CJ Kirkpatrick… - Eur Cell …, 2014 - ecmjournal.org
According to present knowledge, blood derived endothelial progenitor cells (EPC) might act
as proangiogenic myeloid cells, which play a fundamental role in the regulation of …

Engineering vascularized bone graft with osteogenic and angiogenic lineage differentiated bone marrow mesenchymal stem cells

R Zhang, Z Gao, W Geng, X Yan, F Chen… - Artificial organs, 2012 - Wiley Online Library
Tissue‐engineered bone provides a promising method for the rehabilitation of acquired
bone defects and congenital deformities. However, generating a vascular supply to the …

Promotion of osteogenesis in tissue‐engineered bone by pre‐seeding endothelial progenitor cells‐derived endothelial cells

H Yu, PJ VandeVord, W Gong, B Wu… - Journal of …, 2008 - Wiley Online Library
In addition to a biocompatible scaffold and an osteogenic cell population, tissue‐engineered
bone requires an appropriate vascular bed to overcome the obstacle of nutrient and oxygen …