Exuberant elevation of IP-10, MCP-3 and IL-1ra during SARS-CoV-2 infection is associated with disease severity and fatal outcome

Y Yang, C Shen, J Li, J Yuan, M Yang, F Wang, G Li… - MedRxiv, 2020 - medrxiv.org
The outbreak of Coronavirus Disease 2019 (COVID-19) caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, December 2019 …

Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors

H Han, Q Ma, C Li, R Liu, L Zhao, W Wang… - Emerging microbes & …, 2020 - Taylor & Francis
Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, it has rapidly
spread across many other countries. While the majority of patients were considered mild …

[HTML][HTML] The anti-inflammatory cytokine response characterized by elevated interleukin-10 is a stronger predictor of severe disease and poor outcomes than the pro …

BM Henry, SW Benoit, J Vikse, BA Berger… - Clinical Chemistry and …, 2021 - degruyter.com
Objectives Severe coronavirus disease 2019 (COVID-19) is associated with a dysregulated
immune state. While research has focused on the hyperinflammation, little research has …

[HTML][HTML] Sepsis-associated severe interleukin-6 storm in critical coronavirus disease 2019

L Huang, X Zhao, Y Qi, H Li, G Ye, Y Liu… - Cellular & molecular …, 2020 - nature.com
Coronavirus disease 2019 (COVID-19) is a respiratory disease caused by a novel
coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 1, 2 …

[HTML][HTML] Interleukin-6 is a biomarker for the development of fatal severe acute respiratory syndrome coronavirus 2 pneumonia

A Santa Cruz, A Mendes-Frias, AI Oliveira… - Frontiers in …, 2021 - frontiersin.org
Hyper-inflammatory responses induced by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) are a major cause of disease severity and death. Predictive prognosis …

[HTML][HTML] Cytokine signature associated with disease severity in COVID-19

J Guo, S Wang, H Xia, D Shi, Y Chen, S Zheng… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19) broke out and then became a global epidemic at the
end of 2019. With the increasing number of deaths, early identification of disease severity …

[HTML][HTML] Longitudinal cytokine profile in patients with mild to critical COVID-19

L Ling, Z Chen, G Lui, CK Wong, WT Wong… - Frontiers in …, 2021 - frontiersin.org
The cytokine release syndrome has been proposed as the driver of inflammation in
coronavirus disease 2019 (COVID-19). However, studies on longitudinal cytokine profiles in …

Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19

Y Yang, C Shen, J Li, J Yuan, J Wei, F Huang… - Journal of Allergy and …, 2020 - Elsevier
Background The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe
acute respiratory syndrome coronavirus 2 was first reported in Wuhan, December 2019, and …

[HTML][HTML] High levels of circulating IL-8 and soluble IL-2R are associated with prolonged illness in patients with severe COVID-19

A Ma, L Zhang, X Ye, J Chen, J Yu, L Zhuang… - Frontiers in …, 2021 - frontiersin.org
Objectives The coordinated immune response of the host is the key of the successful combat
of the body against SARS-CoV-2 infection and is decisive for the development and …

[HTML][HTML] Immune dysfunction leads to mortality and organ injury in patients with COVID-19 in China: insights from ERS-COVID-19 study

D Li, Y Chen, H Liu, Y Jia, F Li, W Wang, J Wu… - … and Targeted Therapy, 2020 - nature.com
A series of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) since the end of 2019 is ongoing and triggering a …