The roles of neutrophils in cytokine storms

L Chan, N Karimi, S Morovati, K Alizadeh, JE Kakish… - Viruses, 2021 - mdpi.com
A cytokine storm is an abnormal discharge of soluble mediators following an inappropriate
inflammatory response that leads to immunopathological events. Cytokine storms can occur …

Neutrophils at the crossroads of acute viral infections and severity

S Rawat, S Vrati, A Banerjee - Molecular Aspects of Medicine, 2021 - Elsevier
Neutrophils are versatile immune effector cells essential for mounting a first-line defense
against invading pathogens. However, uncontrolled activation can lead to severe life …

Neutrophil in viral infections, friend or foe?

B Drescher, F Bai - Virus research, 2013 - Elsevier
Polymorphonuclear leukocytes or neutrophils are the first immune cells to the site of injury
and microbial infection. Neutrophils are crucial players in controlling bacterial and fungal …

Pathogenesis and treatment of cytokine storm induced by infectious diseases

XD Tang, TT Ji, JR Dong, H Feng, FQ Chen… - International journal of …, 2021 - mdpi.com
Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that
most often occur after an overreactive immune system is activated by an acute systemic …

Role of neutrophils in acute viral infection

Y Ma, Y Zhang, L Zhu - Immunity, inflammation and disease, 2021 - Wiley Online Library
Neutrophils play multiple roles in acute viral infections. They restrict viral replication and
diffusion through phagocytosis, degranulation, respiratory burst, secretion of cytokines, and …

Neutrophil functional heterogeneity and implications for viral infections and treatments

L Chan, S Morovati, N Karimi, K Alizadeh… - Cells, 2022 - mdpi.com
Evidence suggests that neutrophils exert specialized effector functions during infection and
inflammation, and that these cells can affect the duration, severity, and outcome of the …

Neutrophils in viral infection

V Naumenko, M Turk, CN Jenne, SJ Kim - Cell and tissue research, 2018 - Springer
Neutrophils are the first wave of recruited immune cells to sites of injury or infection and are
crucial players in controlling bacterial and fungal infections. Although the role of neutrophils …

Neutrophils in viral infections: current concepts and caveats

IE Galani, E Andreakos - Journal of Leucocyte Biology, 2015 - academic.oup.com
Neutrophils are the first immune cell population recruited to sites of infection, including viral
infections, and exhibit both protective and pathologic functions. In antibacterial and …

Into the eye of the cytokine storm

JR Tisoncik, MJ Korth, CP Simmons… - Microbiology and …, 2012 - Am Soc Microbiol
The cytokine storm has captured the attention of the public and the scientific community
alike, and while the general notion of an excessive or uncontrolled release of …

Virus-induced NETs–critical component of host defense or pathogenic mediator?

CN Jenne, P Kubes - PLoS pathogens, 2015 - journals.plos.org
Much of the effort to understand and regulate the host antiviral response has been focused
on adaptive immunity including high affinity, neutralizing antibody production, and the …