Retroviral replication proceeds through obligate integration of the viral DNA into the host
genome. In particular, for the HIV-1 genome to enter the nucleus, it must be led through the …

During uncoating, the conical capsid of HIV disassembles by dissociation of the p24 capsid
protein (CA). Uncoating is known to be required for HIV replication, but the mechanism is …

After budding, the human immunodeficiency virus (HIV) must 'mature'into an infectious viral
particle. Viral maturation requires proteolytic processing of the Gag polyprotein at the matrix …

The murine leukaemia virus (MLV) Gag cleavage product, p12, is essential for both early
and late steps in viral replication. The N-terminal domain of p12 binds directly to capsid (CA) …

During HIV-1 infection of cells, the viral capsid plays critical roles in reverse transcription and
nuclear entry of the virus. The capsid-targeting small molecule PF74 inhibits HIV-1 at early …

The RNA genome of human immunodeficiency virus type 1 (HIV-1) is enclosed in a cone-
shaped capsid shell that disassembles following cell entry via a process known as …

Human immunodeficiency virus type 1 (HIV-1), like other lentiviruses, can infect non-dividing
cells. The lentiviruses are most likely to have evolved a nuclear import strategy to import HIV …

During the morphogenesis of mature human immunodeficiency virus-1 cores, viral capsid
proteins assemble conical or tubular shells around viral ribonucleoprotein complexes. This …

The HIV capsid self-assembles a protective conical shell that simultaneously prevents host
sensing whilst permitting the import of nucleotides to drive DNA synthesis. This is …

Cleavage and polyadenylation specificity factor 6 (CPSF6) is a human protein that binds HIV-
1 capsid and mediates nuclear transport and integration targeting of HIV-1 preintegration …