Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome

LYC Chen, RL Hoiland, S Stukas… - European …, 2020 - Eur Respiratory Soc
The concept of coronavirus disease 2019 (COVID-19)-related cytokine storm syndrome
(COVID-CSS) emerged early in the severe acute respiratory syndrome coronavirus 2 (SARS …

[HTML][HTML] Cytokine storm in COVID-19: the current evidence and treatment strategies

Y Tang, J Liu, D Zhang, Z Xu, J Ji, C Wen - Frontiers in immunology, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is the pathogen that causes
coronavirus disease 2019 (COVID-19). As of 25 May 2020, the outbreak of COVID-19 has …

Cytokine storm induced by SARS-CoV-2

P Song, W Li, J Xie, Y Hou, C You - Clinica chimica acta, 2020 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19), caused by the virus designated as severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread widely throughout the …

[HTML][HTML] Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

DE Leisman, L Ronner, R Pinotti, MD Taylor… - The Lancet …, 2020 - thelancet.com
The description of a so-called cytokine storm in patients with COVID-19 has prompted
consideration of anti-cytokine therapies, particularly interleukin-6 antagonists. However …

Cytokines and COVID-19: friends or foes?

M Rokni, MR Hamblin, N Rezaei - Human vaccines & …, 2020 - Taylor & Francis
The cytokine storm following sepsis has been proven to be an important mechanism for
triggering acute respiratory distress syndrome, which is a fatal uncontrolled systemic …

[HTML][HTML] Potential treatments for COVID-19 related cytokine storm-beyond corticosteroids

Y Miao, L Fan, JY Li - Frontiers in Immunology, 2020 - frontiersin.org
A novel virus, SARS-CoV-2, emerged in Wuhan in December 2019 and rapidly spread to
other cities in China and other countries. Several studies have summarized the clinical …

[HTML][HTML] COVID-19 infection: an overview on cytokine storm and related interventions

S Montazersaheb, SM Hosseiniyan Khatibi, MS Hejazi… - Virology journal, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. This …

Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and …

J Wang, M Jiang, X Chen… - Journal of Leucocyte …, 2020 - academic.oup.com
Clinical evidence indicates that the fatal outcome observed with severe acute respiratory
syndrome-coronavirus-2 infection often results from alveolar injury that impedes airway …

[HTML][HTML] Cytokine storm in COVID-19:“when you come out of the storm, you won't be the same person who walked in”

V Castelli, A Cimini, C Ferri - Frontiers in immunology, 2020 - frontiersin.org
In December 2019, a novel coronavirus, COVID-19, was discovered to be the causal agent
of a severe respiratory infection named SARS-CoV-2, and it has since been recognized …

An enlightening role for cytokine storm in coronavirus infection

Z Zhao, Y Wei, C Tao - Clinical Immunology, 2021 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in Wuhan,
China has dispersed rapidly worldwide. Although most patients present with mild fever …