[HTML][HTML] Single-cell transcriptomes distinguish stem cell state changes and lineage specification programs in early mammary gland development
The mammary gland consists of cells with gene expression patterns reflecting their cellular
origins, function, and spatiotemporal context. However, knowledge of developmental …
origins, function, and spatiotemporal context. However, knowledge of developmental …
Think globally, act locally: the making of a mouse mammary gland
L Hennighausen, GW Robinson - Genes & development, 1998 - genesdev.cshlp.org
On a phylogenetic scale of organ development the mammary gland is a recent acquisition. It
was introduced 200 million years ago with the appearance of mammals to provide …
was introduced 200 million years ago with the appearance of mammals to provide …
Evaluation of mammary gland development and function in mouse models
I Plante, MKG Stewart, DW Laird - JoVE (Journal of Visualized …, 2011 - jove.com
The human mammary gland is composed of 15-20 lobes that secrete milk into a branching
duct system opening at the nipple. Those lobes are themselves composed of a number of …
duct system opening at the nipple. Those lobes are themselves composed of a number of …
[HTML][HTML] Stem cells and the differentiation hierarchy in mammary gland development
NY Fu, E Nolan, GJ Lindeman… - Physiological …, 2020 - journals.physiology.org
The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …
epithelium during puberty and the reproductive cycle. These changes are fueled by …
Mammary stem cells and the differentiation hierarchy: current status and perspectives
JE Visvader, J Stingl - Genes & development, 2014 - genesdev.cshlp.org
The mammary epithelium is highly responsive to local and systemic signals, which
orchestrate morphogenesis of the ductal tree during puberty and pregnancy. Based on …
orchestrate morphogenesis of the ductal tree during puberty and pregnancy. Based on …
Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling
The mammary epithelium comprises two primary cellular lineages, but the degree of
heterogeneity within these compartments and their lineage relationships during …
heterogeneity within these compartments and their lineage relationships during …
Molecular mechanisms guiding embryonic mammary gland development
P Cowin, J Wysolmerski - Cold Spring Harbor …, 2010 - cshperspectives.cshlp.org
The mammary gland is an epidermal appendage that begins to form during embryogenesis,
but whose development is only completed during pregnancy. Each mammary gland begins …
but whose development is only completed during pregnancy. Each mammary gland begins …
[HTML][HTML] Differentiation dynamics of mammary epithelial cells revealed by single-cell RNA sequencing
Characterising the hierarchy of mammary epithelial cells (MECs) and how they are
regulated during adult development is important for understanding how breast cancer …
regulated during adult development is important for understanding how breast cancer …
Embryonic mammary gland development
Embryonic mammary gland development involves the formation of mammary placodes,
invagination of flask-shaped mammary buds and development of miniature bi-layered ductal …
invagination of flask-shaped mammary buds and development of miniature bi-layered ductal …
Morphogenesis of mammary gland development
Abstract Development of the mammary gland in females is a dynamic, orchestrated process
that occurs throughout postnatal development. Initiated during embryogenesis, epithelial …
that occurs throughout postnatal development. Initiated during embryogenesis, epithelial …