During puberty the mammary gland develops from a rudimentary tree to a branched
epithelial network of ducts which can support alveolar development and subsequent milk …

The mammary epithelium undergoes enormous morphogenetic changes during the lifespan
of a mammal. The recent elucidation of an epithelial differentiation hierarchy in the mouse …

Adult mammary stem cells (MaSCs) drive postnatal organogenesis and remodeling in the
mammary gland, and their longevity and potential have important implications for breast …

Our understanding of prenatal morphogenesis of mammary glands has recently greatly
advanced. This review focuses on morphogenesis proper, as well as cellular processes and …

Background Studying the composition and developmental mechanisms in mammary gland
is crucial for healthy growth of newborns. The mammary gland is inherently heterogeneous …

The mammary gland undergoes cycles of growth and regeneration throughout reproductive
life, a process that requires mammary stem cells (MaSCs). Whilst recent genetic fate …

Systemic hormones are key regulators of postnatal mammary gland development and play
an important role in the etiology and treatment of breast cancer. Mammary ductal …

In most adult tissues there reside pools of stem and progenitor cells inside specialized
microenvironments referred to as niches. The niche protects the stem cells from …

The mammary gland undergoes dynamic changes throughout life. In the mouse, these begin
with initial morphogenesis of the gland in the mid-gestation embryo followed by hormonally …

The breast is a dynamic organ whose response to physiological and pathophysiological
conditions alters its disease susceptibility, yet the specific effects of these clinical variables …