Parity-induced mammary epithelial cells (PI-MECs) are defined as a pregnancy hormone-
responsive cell population that activates the promoter of late milk protein genes during the …

Mammary morphogenesis is orchestrated with other reproductive events by pituitary-driven
changes to the systemic hormone environment, initiating the formation of a mammary ductal …

Unlike other branched organs, the mammary gland undergoes most of its branching during
adolescent rather than embryonic development. Its morphogenesis begins in utero, pauses …

Mammary epithelial cell development is thought to progress from undifferentiated stem cells
into at least two differentiated cell types. A new study has now characterized some of these …

Background Studies of normal human mammary gland development and function have
mostly relied on cell culture, limited surgical specimens, and rodent models. Although RNA …

Epithelial cell cultures, including immortalized cells, have been used extensively to help
answer basic questions of mammary gland physiology under normal or diseased conditions …

Although cell number is positively correlated with milk production, much remains to be
learned about the bovine mammary stem cell and progenitor cells. Bovine mammary …

The mammary gland represents a unique tissue to study organogenesis as it predominantly
develops in the post-natal animal and undergoes dramatic morphogenetic changes during …

Dissecting cellular differentiation hierarchies in the mammary gland is a prerequisite for
understanding both normal development and malignant transformation during …

The bovine mammary gland is a favorable organ for studying mammary cell hierarchy due to
its robust milk-production capabilities that reflect the adaptation of its cell populations to …