Cellular pathways that contribute to adult human mammary gland architecture and lineages
have not been previously described. In this study, we identify a candidate stem cell niche in …

To characterize the molecular mechanisms by which progesterone withdrawal initiates milk
secretion, we examined global gene expression during pregnancy and lactation in mice …

An entire mammary epithelial outgrowth, capable of full secretory differentiation, may
comprise the progeny of a single cellular antecedent, ie, may be generated from a single …

Breast milk contains bioactive molecules that provide a multitude of immunologic,
developmental and nutritional benefits to the infant. Less attention has been placed on the …

Introduction Molecular characterization of the normal epithelial cell types that reside in the
mammary gland is an important step toward understanding pathways that regulate self …

The partial purification of mouse mammary gland stem cells (MaSCs) using combinatorial
cell surface markers (Lin− CD24+ CD29hCD49fh) has improved our understanding of their …

The lactating mammary gland contains a stem cells population with multilineage
potentialities. Recently it was also shown that breast milk contains a heterogeneous …

Technological improvements enable single-cell epigenetic analyses of organ development.
We reasoned that high-resolution single-cell chromatin accessibility mapping would provide …

The molecular processes underlying human milk production and the effects of mastitic
infection are largely unknown because of limitations in obtaining tissue samples …

From its embryonic origins, the mammary gland in females undergoes a course of ductal
development that supports the establishment of alveolar structures during pregnancy prior to …