The correspondence of cell state changes in diseased organs to peripheral protein
signatures is currently unknown. Here, we generated and integrated single‐cell …

Rationale: The contributions of diverse cell populations in the human lung to pulmonary
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal …

Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with a significant
unmet medical need. Development of transformational therapies for IPF is challenging in …

Tissue fibrosis is a major cause of mortality that results from the deposition of matrix proteins
by an activated mesenchyme. Macrophages accumulate in fibrosis, but the role of specific …

Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung disease characterized by aberrant
remodeling of the lung parenchyma with extensive changes to the phenotypes of all lung …

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease that is characterized by
replacement of the normal lung anatomy with active remodeling and deposition of …

Progressive pulmonary fibrosis results from a dysfunctional tissue repair response and is
characterized by fibroblast proliferation, activation, and invasion and extracellular matrix …

Rationale: Disease activity in idiopathic pulmonary fibrosis (IPF) remains highly variable,
poorly understood, and difficult to predict. Objectives: To identify a predictor using short-term …

The heterogeneity of idiopathic pulmonary fibrosis (IPF) limits its diagnosis and treatment.
The association between the pathophysiological features and the serum protein signatures …

The pathophysiology of cystic fibrosis (CF) lung disease remains incompletely understood.
Novel mechanisms in the pathogenesis of CF lung disease may be discovered by studying …