[HTML][HTML] Protective efficacy of neutralizing monoclonal antibodies in a nonhuman primate model of Ebola hemorrhagic fever

A Marzi, R Yoshida, H Miyamoto, M Ishijima, Y Suzuki… - PloS one, 2012 - journals.plos.org
Ebola virus (EBOV) is the causative agent of severe hemorrhagic fever in primates, with
human case fatality rates up to 90%. Today, there is neither a licensed vaccine nor a …

[HTML][HTML] Ebola GP-specific monoclonal antibodies protect mice and guinea pigs from lethal Ebola virus infection

X Qiu, L Fernando, PL Melito, J Audet… - PLoS neglected …, 2012 - journals.plos.org
Ebola virus (EBOV) causes acute hemorrhagic fever in humans and non-human primates
with mortality rates up to 90%. So far there are no effective treatments available. This study …

Protective efficacy of neutralizing antibodies against Ebola virus infection

A Takada, H Ebihara, S Jones, H Feldmann… - Vaccine, 2007 - Elsevier
Ebola virus causes lethal hemorrhagic fever in humans and nonhuman primates, but no
effective antiviral compounds are available for the treatment of this infection. The surface …

Immune parameters correlate with protection against ebola virus infection in rodents and nonhuman primates

G Wong, JS Richardson, S Pillet, A Patel… - Science translational …, 2012 - science.org
Ebola virus causes severe hemorrhagic fever in susceptible hosts. Currently, no licensed
vaccines or treatments are available; however, several experimental vaccines have been …

[HTML][HTML] Molecular characterization of the monoclonal antibodies composing ZMAb: a protective cocktail against Ebola virus

J Audet, G Wong, H Wang, G Lu, GF Gao, G Kobinger… - Scientific reports, 2014 - nature.com
Ebola virus (EBOV) causes severe viral hemorrhagic fever in humans and non-human
primates, with a case fatality rate of up to 88% in human outbreaks. Over the past 3 years …

Novel cross-reactive monoclonal antibodies against ebolavirus glycoproteins show protection in a murine challenge model

J Duehr, TJ Wohlbold, L Oestereich… - Journal of …, 2017 - Am Soc Microbiol
Out of an estimated 31,100 cases since their discovery in 1976, ebolaviruses have caused
approximately 13,000 deaths. The vast majority (∼ 11,000) of these occurred during the …

Successful treatment of Ebola virus–infected cynomolgus macaques with monoclonal antibodies

X Qiu, J Audet, G Wong, S Pillet, A Bello… - Science translational …, 2012 - science.org
Ebola virus (EBOV) is considered one of the most aggressive infectious agents and is
capable of causing death in humans and nonhuman primates (NHPs) within days of …

An Ebola whole-virus vaccine is protective in nonhuman primates

A Marzi, P Halfmann, L Hill-Batorski, F Feldmann… - Science, 2015 - science.org
Zaire ebolavirus is the causative agent of the current outbreak of hemorrhagic fever disease
in West Africa. Previously, we showed that a whole Ebola virus (EBOV) vaccine based on a …

[HTML][HTML] Sustained protection against Ebola virus infection following treatment of infected nonhuman primates with ZMAb

X Qiu, J Audet, G Wong, L Fernando, A Bello, S Pillet… - Scientific reports, 2013 - nature.com
Ebola virus (EBOV) is one of the most lethal filoviruses, with mortality rates of up to 90% in
humans. Previously, we demonstrated 100% and 50% survival of EBOV-infected …

Development of clinical-stage human monoclonal antibodies that treat advanced Ebola virus disease in nonhuman primates

KE Pascal, D Dudgeon, JC Trefry… - The Journal of …, 2018 - academic.oup.com
Background For most classes of drugs, rapid development of therapeutics to treat emerging
infections is challenged by the timelines needed to identify compounds with the desired …