Chronic pancreatitis (CP) is a fibro-inflammatory disease leading to pain, maldigestion, and
pancreatic insufficiency. No therapeutic options exist due to a limited understanding of the …

Pancreas fibrosis is the result of a dynamic cascade of mechanisms beginning with acinar
cell (AC) injury and necrosis and followed by inflammation, activation of macrophages …

The conventional view of the pathogenesis of acute and chronic pancreatitis is that it is due
to a genetic-or environment-based abnormality of intracellular acinar trypsinogen activation …

Acute pancreatitis (AP) is characterized by release of proteolytic enzymes from the pancreas
and a powerful inflammatory cytokine cascade that mediates the systemic manifestations …

Background: Neutrophil extracellular traps (NETs) are generated when activated
neutrophils, driven by PAD4, release their DNA, histones, HMGB1, and other intracellular …

Cytokines produced by pancreatic acinar cells may mediate cell death and recruitment of
inflammatory cells into pancreas in pancreatitis and other disorders. Here, we demonstrate …

There is increasing evidence showing that chronic inflammation is an important pathogenic
mediator of the development of type 2 diabetes (T2D). It is now generally accepted that …

Pancreatic stellate cells (PaSCs) are myofibroblast-like cells found in the areas of the
pancreas that have exocrine function. PaSCs are regulated by autocrine and paracrine …

Inflammatory mediators play a key role in acute pancreatitis and the resultant multiple organ
dysfunction syndrome, which is the primary cause of death in this condition. Recent studies …

Background Acute pancreatitis has long been considered a disorder of pancreatic self-
digestion, in which intracellular activation of digestive proteases induces tissue injury …