Inflammation is the tissues' defense response after the body is stimulated by microbial
infection or damage signals, and it is initiated when pattern recognition receptors recognize …

The NLRP3 inflammasome holds a crucial role in innate immune responses. Pathogen-and
danger-associated molecular patterns may initiate inflammasome activation and following …

Inflammasome activation initiates the development of many inflammatory diseases,
including obesity and type 2 diabetes. Therefore, agents that target discrete activation steps …

Inflammasomes are multiprotein complexes having nucleotide-binding domain and leucine-
rich repeat consisting members along with pyrin and HIN domain family. An inflammasome …

The NLR family, pyrin domain‐containing 3 (NLRP3) inflammasome is a multiprotein
complex that induces caspase‐1 activation and the downstream substrates involved with the …

Ginsenoside Rg3 is one of the main constituents of Panax ginseng. Compelling evidence
has demonstrated that ginsenoside Rg3 is capable of inhibiting inflammation. However, the …

Background and Purpose The NLR family pyrin domain‐containing 3 (NLRP3)
inflammasome is activated in many inflammatory conditions. So far, no low MW compounds …

Diabetes, a common metabolic disease with various complications, is becoming a serious
global health pandemic. So far there are many approaches in the management of diabetes; …

Nod-like receptor protein 3 (NLRP3), a therapeutic target that has a close relationship with
inflammatory diseases, has drawn significant attention from researchers in the field. An …

Fibrosis is a common pathway followed by different organs after injury, and it can lead to
parenchymal scarring, cellular dysfunction, and even organ failure. The NLRP3 …