538P First-line chemoimmunotherapy for metastatic thymic carcinoma

VJ Andreas, M Alexander, J Rogers… - Annals of …, 2023 - annalsofoncology.org
Background Thymic carcinoma (TC) is a rare, aggressive cancer without a standardized
therapeutic approach in the metastatic context. Recently TCs have been shown to express …

112O Primary result of an investigator-initiated phase II trial of nivolumab for unresectable or recurrent thymic carcinoma: PRIMER study (NCCH1505)

T Seto, Y Katsuya, H Horinouchi, S Umemura… - Journal of Thoracic …, 2018 - jto.org
Background: Thymic carcinoma (TC) is a rare cancer with a poor prognosis. Treatment
options are limited, especially after relapse. We previously reported that PD-L1 positivity was …

[HTML][HTML] Single-arm, multicentre, phase II trial of nivolumab for unresectable or recurrent thymic carcinoma: PRIMER study

Y Katsuya, H Horinouchi, T Seto, S Umemura… - European Journal of …, 2019 - Elsevier
Introduction Thymic carcinoma (TC) is a rare cancer with a poor prognosis and limited
treatment options, especially after relapse. Methods In this open-label, two-stage …

Immunotherapy for thymic cancers: a convoluted path toward a cherished goal

A Rajan - Journal of Thoracic Oncology, 2021 - jto.org
The remarkable success of immune checkpoint inhibitors (ICIs) against several cancers has
had a significant impact on the management of these diseases and marked the beginning of …

2186P KN046 in patients with thymic carcinoma: A prospective, single-arm, multi-centre, phase II study

W Fang, C Wang, J Li, M Chen, Y Ji, H Fan… - Annals of …, 2023 - annalsofoncology.org
Background Thymic carcinoma (TC) is a rare but highly aggressive cancer, with no standard
treatment for patients who progress after platinum-containing chemotherapy. KN046 is a …

Immunotherapy vs platinum for advanced or metastatic thymic carcinoma: A protocol for systematic review and meta analysis

J Qian, Z Tong, Y Zhang, C Chen - Medicine, 2021 - journals.lww.com
Background: Thymic carcinoma is a rare malignancy, and platinum-based chemotherapy
has not previously been established as a standard treatment for advanced or metastatic …

Chemotherapy versus chemotherapy plus immune checkpoint inhibitors for the first‐line treatment of unresectable thymic carcinoma: A multicenter retrospective study

B Zhang, Y Liu, Z Chen, J Chen, H Yu… - … Journal of Cancer, 2024 - Wiley Online Library
Thymic carcinoma (TC) is a rare malignant tumor with a poor prognosis, and there is
currently limited data on the use of immunotherapy in patients with unresectable TC. In this …

Pembrolizumab in patients with thymic carcinoma: a single-arm, single-centre, phase 2 study

G Giaccone, C Kim, J Thompson, C McGuire… - The Lancet …, 2018 - thelancet.com
Background Treatment options are limited for patients with thymic carcinoma. These
aggressive tumours are not typically associated with paraneoplastic autoimmune disorders …

[HTML][HTML] Successful use of pembrolizumab to treat refractory thymic carcinoma with high PD-L1 expression

T Isshiki, K Isobe, N Tochigi, M Sunakawa… - Case Reports in …, 2018 - karger.com
Thymic carcinoma is a relatively rare and aggressive thymic epithelial tumor. Herein, we
report successful treatment of thymic carcinoma with pembrolizumab. A 68-year-old woman …

MA20. 05 Follow-Up Update of 2 Phase II Studies of Pembrolizumab in Thymic Carcinoma

G Giaccone, J Cho, C Kim, M Ahn - Journal of Thoracic Oncology, 2019 - jto.org
Background Two phase II studies of pembrolizumab 200 mg every 3 weeks in advanced
thymic carcinoma have recently been published (Giaccone et al. Lancet Oncol. 2018, study# …