Enabling sensitive phenotypic profiling of cancer-derived small extracellular vesicles using surface-enhanced Raman spectroscopy nanotags

W Zhang, L Jiang, RJ Diefenbach, DH Campbell… - ACS …, 2020 - ACS Publications
Circulating cancer-derived small extracellular vesicles (EVs) are nanoscale membranous
vesicles shed from cancer cells that are released into surrounding body fluids. Small EVs …

Emerging integrated SERS-microfluidic devices for analysis of cancer-derived small extracellular vesicles

L Ngo, A Tukova, A Hassanzadeh-Barforoushi… - Lab on a Chip, 2023 - pubs.rsc.org
Cancer-derived small extracellular vesicles (sEVs) are specific subgroups of lipid bilayer
vesicles secreted from cancer cells to the extracellular environment. They carry distinct …

Single particle automated Raman trapping analysis of breast cancer cell-derived extracellular vesicles as cancer biomarkers

J Penders, A Nagelkerke, EM Cunnane, SV Pedersen… - ACS …, 2021 - ACS Publications
Extracellular vesicles (EVs) secreted by cancer cells provide an important insight into cancer
biology and could be leveraged to enhance diagnostics and disease monitoring. This paper …

Characterizing the Heterogeneity of Small Extracellular Vesicle Populations in Multiple Cancer Types via an Ultrasensitive Chip

J Wang, A Wuethrich, RJ Lobb, F Antaw, AAI Sina… - ACS …, 2021 - ACS Publications
Identifying small extracellular vesicle (sEV) subpopulations based on their different
molecular signatures could potentially reveal the functional roles in physiology and …

Extracellular vesicle identification using label-free surface-enhanced raman spectroscopy: detection and signal analysis strategies

H Shin, D Seo, Y Choi - Molecules, 2020 - mdpi.com
Extracellular vesicles (EVs) have been widely investigated as promising biomarkers for the
liquid biopsy of diseases, owing to their countless roles in biological systems. Furthermore …

Immuno-capture of extracellular vesicles for individual multi-modal characterization using AFM, SEM and Raman spectroscopy

P Beekman, A Enciso-Martinez, HS Rho, SP Pujari… - Lab on a Chip, 2019 - pubs.rsc.org
Tumor-derived extracellular vesicles (tdEVs) are promising blood biomarkers for cancer
disease management. However, blood is a highly complex fluid that contains multiple …

MoS2-Plasmonic Nanocavities for Raman Spectra of Single Extracellular Vesicles Reveal Molecular Progression in Glioblastoma

M Jalali, C del Real Mata, L Montermini, O Jeanne… - ACS …, 2023 - ACS Publications
Extracellular vesicles (EVs) are continually released from cancer cells into biofluids, carrying
actionable molecular fingerprints of the underlying disease with considerable diagnostic and …

An integrated microfluidic‐SERS platform enables sensitive phenotyping of serum extracellular vesicles in early stage melanomas

J Wang, YC Kao, Q Zhou, A Wuethrich… - Advanced Functional …, 2022 - Wiley Online Library
Precise detection of early melanomas is essential as the stage of disease guides treatment
options. One growing field that may facilitate the advancement of early melanoma detection …

Molecular Stratification and Treatment Monitoring of Lung Cancer Using a Small Extracellular Vesicle-Activated Nanocavity Architecture

J Li, M Li, A Wuethrich, R Guan, L Zhao, C Hu… - Analytical …, 2024 - ACS Publications
Development of molecular diagnostics for lung cancer stratification and monitoring is crucial
for the rational planning and timely adjustment of treatments to improve clinical outcomes. In …

Improving SERS biosensors for the analysis of ovarian cancer-derived small extracellular vesicles

L Ngo, W Zhang, SST Hnit, Y Wang - Analyst, 2023 - pubs.rsc.org
Small extracellular vesicles (sEVs) are lipid bilayer vesicles that carry key molecules (eg,
proteins, DNAs, RNAs, and lipids) for cell-to-cell communication, being regarded as …